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Review
. 2024 Jul 1;30(4):352-358.
doi: 10.1097/MCP.0000000000001063. Epub 2024 Feb 26.

Lobar or sublobar resection of peripheral stage I non-small cell lung cancer

Pedro Guimarães Rocha Lima  1   2 , Matthieu Glorion  1   2 , Moishe Liberman  1   2
Affiliations
Review

Lobar or sublobar resection of peripheral stage I non-small cell lung cancer

Pedro Guimarães Rocha Lima et al. Curr Opin Pulm Med. .

Abstract

Purpose of review: We aim to highlight two recent clinical trials that have altered the approach of the management of stage I nonsmall cell lung cancer.

Recent findings: The JCOG 0802 and CALGB 140503 trials demonstrated that sublobar resection is noninferior to lobectomy for overall and disease-free survival in patients with stage I nonsmall cell lung cancer.

Summary: Since 1962, lobectomy has been deemed the gold standard treatment for operable lung cancer. However, two recent clinical trials have demonstrated that, for select patients, sublobar resection is oncologically noninferior; results, which are leading us into a new era for the surgical management of lung cancer. Notwithstanding the progress made by these studies and the opportunities that have been put forth, questions remain. This review aims at reviewing the results of both trials and to discuss future perspectives for the surgical treatment of lung cancer.

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References

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    1. Shimkin MB, Connelly RR, Marcus SC, Cutler SJ. Pneumonectomy and lobectomy in bronchogenic carcinoma: a comparison of end results of the Overholt and Ochsner clinics. J Thorac Cardiovasc Surg 1962; 44:503–519.
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    1. Altorki N, Wang X, Kozono D, et al. Lobar or sublobar resection for peripheral stage IA non–small-cell lung cancer. N Engl J Med 2023; 388:489–498.

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