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Comment
. 2024 Apr 29;115(5):794-796.
doi: 10.1093/jleuko/qiae044.

Broad-spectrum defenders: γδ T cells take on a multitude of immune challenges

Julian J Freen-van Heeren  1
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Broad-spectrum defenders: γδ T cells take on a multitude of immune challenges

Julian J Freen-van Heeren. J Leukoc Biol. .

Abstract

A recent article in Proceedings of the National Academy of Sciences investigated γδ T cell antigen specificity in mice and humans, in which the authors show that γδ T cell antigen specificity is not constrained to one epitope. Rather, γδ T cells recognize a broad range of diverse antigens containing similar chemical structures or properties. In this News and Views, the importance of γδ T cell antigen polyspecificity during immune responses is highlighted.

Keywords: adaptive immune cells; antigen recognition; antigen specificity; gamma delta T cells; polyspecificity.

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Conflict of interest statement. None declared.

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