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. 2024 Feb 27;15(1):64.
doi: 10.1186/s13244-024-01629-4.

The value of periportal hyperintensity sign from gadobenate dimeglumine-enhanced hepatobiliary phase MRI for predicting clinical outcomes in patients with decompensated cirrhosis

Lanqing Cong #  1 , Yan Deng #  2 , Shuo Cai  3 , Gongzheng Wang  4 , Xinya Zhao  1 , Jingzhen He  2 , Songbo Zhao  5   6 , Li Wang  7
Affiliations

The value of periportal hyperintensity sign from gadobenate dimeglumine-enhanced hepatobiliary phase MRI for predicting clinical outcomes in patients with decompensated cirrhosis

Lanqing Cong et al. Insights Imaging. .

Erratum in

Abstract

Objectives: To determine the value of periportal hyperintensity sign from gadobenate dimeglumine (Gd-BOPTA)-enhanced hepatobiliary phase (HBP) magnetic resonance imaging (MRI) for predicting clinical outcomes in patients with decompensated cirrhosis.

Methods: A total of 199 cirrhotic patients who underwent Gd-BOPTA-enhanced MRI were divided into control group (n = 56) and decompensated cirrhosis group (n = 143). The presence of periportal hyperintensity sign on HBP MRI was recorded. The Cox regression model was used to investigate the association between periportal hyperintensity sign and clinical outcomes.

Results: There was a significant difference in the frequency of periportal hyperintensity sign on HBP between compensated and decompensated cirrhotic patients (p < 0.05). After a median follow-up of 29.0 months (range, 1.0-90.0 months), nine out of 143 patients (6.2%) with decompensated cirrhosis died. Periportal hyperintensity sign on HBP MRI was a significant risk factor for death (hazard ratio (HR) = 23.677; 95% confidence interval (CI) = 4.759-117.788; p = 0.0001), with an area under the curve (AUC) of 0.844 (95% CI = 0.774-0.899). Thirty patients (20.9%) developed further decompensation. Periportal hyperintensity sign on HBP MRI was also a significant risk factor for further decompensation (HR = 2.594; 95% CI = 1.140-5.903; p = 0.023).

Conclusions: Periportal hyperintensity sign from Gd-BOPTA-enhanced HBP MRI is valuable for predicting clinical outcomes in patients with decompensated cirrhosis.

Critical relevance statement: Periportal hyperintensity sign from gadobenate dimeglumine-enhanced hepatobiliary phase magnetic resonance imaging is a new noninvasive method to predict clinical outcomes in patients with decompensated cirrhosis.

Key points: • There was a significant difference in the frequency of periportal hyperintensity sign on HBP between compensated and decompensated cirrhotic patients. • Periportal hyperintensity sign on the hepatobiliary phase was a significant risk factor for death in patients with decompensated cirrhosis. • Periportal hyperintensity sign on the hepatobiliary phase was a significant risk factor for further decompensation in patients with decompensated cirrhosis.

Keywords: Gadobenate dimeglumine, Periportal hyperintensity sign, Liver cirrhosis, Magnetic resonance imaging, Clinical outcomes.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The pre-contrast T1-weighted image (a) and HBP image (b) were selected from a 57-year-old compensated cirrhotic patient. Periportal hyperintensity on HBP is not observed in this patient. The pre-contrast T1-weighted image (c) and HBP image (d) were selected from a 48-year-old decompensated cirrhotic patient. Periportal hyperintensity on HBP is observed (black arrow) in this patient. HBP, hepatobiliary phase
Fig. 2
Fig. 2
Kaplan–Meier curves for patients with decompensated cirrhosis. a Cumulative incidence of death in patients with periportal hyperintensity sign on HBP compared to those without the sign. b Cumulative incidence of further decompensation in patients with periportal hyperintensity sign on HBP compared to those without the sign. HBP, hepatobiliary phase
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