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. 2024 Feb 26;4(2):100719.
doi: 10.1016/j.crmeth.2024.100719.

Focused ultrasound-mediated delivery of viral neuronal tracers in marmosets

Bernie S Owusu-Yaw  1 , Nick Todd  2
Affiliations

Focused ultrasound-mediated delivery of viral neuronal tracers in marmosets

Bernie S Owusu-Yaw et al. Cell Rep Methods. .

Abstract

In this issue of Cell Reports Methods, Parks et al. present an approach to non-invasively deliver adeno-associated viruses in a marmoset model using focused ultrasound (FUS) for neuronal tracing. The optimization of this technique in this non-human primate model is highly valuable for future FUS-mediated drug delivery studies.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1
Illustration of FUS-mediated AAV delivery in a Marmoset model The marmosets were treated with FUS targeting the right area 8aD. BBB disruption was confirmed with MRI before the systemic delivery of AAV9 or AAV2. 4 to 6 weeks after treatment, the marmosets were euthanized, and the brains were harvested for immunofluorescence staining. Figure created using BioRender (https://biorender.com).
See this image and copyright information in PMC

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