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. 2024 Feb 27;14(1):4729.
doi: 10.1038/s41598-024-54378-1.

Association of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study

Shao Yi He  1   2 , Wei Sen Zhang  3   4 , Chao Qiang Jiang  5   2 , Ya Li Jin  5   2 , Tai Hing Lam  6   2 , Kar Keung Cheng  7   2 , Lin Xu  8   9   10   11
Affiliations

Association of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study

Shao Yi He et al. Sci Rep. .

Abstract

To examine the association of adverse childhood experiences (ACEs) with anemia among older people. 24,116 participants aged 50 years or above were recruited. Multivariable linear and logistic regression was used to assess the associations of self-reported ACEs number with hemoglobin concentrations (g/dL) and presence of anemia. Older individuals with two or more ACEs, versus no ACEs, showed lower hemoglobin concentrations (β = - 0.08 g/dL, 95% confidence intervals (CI) - 0.12 to - 0.03) and higher odds of anemia (odds ratio = 1.26, 95% CI 1.01-1.59). A more pronounced association between ACEs and anemia in the lower education group was found, while the association became non-significant in those with higher education (P for ACEs-education interaction = 0.02). ACEs was associated with anemia in older people, and the association was stronger in those with lower education, highlighting the significance of early-life psychological stressors assessment and consideration of education background in geriatric care.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Directed acyclic graph (DAG) of factors associated with anemia in Guangzhou Biobank Cohort Study. ACEs adverse childhood experiences; BMI body mass index. Note Green lines indicated causal paths. Pink lines indicated biasing paths. Pink dots were potential confounders which were ancestors of exposure and outcome. Blue dots were latent mediators.
Figure 2
Figure 2
Association of ACEs (Yes vs. No) with anemia by demographic characteristics and socioeconomic status in Guangzhou Biobank Cohort Study. OR odds ratio; CI confidence interval, ACEs adverse childhood experiences. Note This model adjusted for sex, age, education status and childhood socioeconomic status.
See this image and copyright information in PMC

References

    1. Safiri S, et al. Burden of anemia and its underlying causes in 204 countries and territories, 1990–2019: Results from the Global Burden of Disease Study 2019. J. Hematol. Oncol. 2021;14:1–16. doi: 10.1186/s13045-021-01202-2. - DOI - PMC - PubMed
    1. Liming, L. et al. A description on the Chinese national nutrition and health survey in 2002. Chin. J. Epidemiol., 478–484 (2005). - PubMed
    1. Lee C-T, et al. Prevalence of anemia and its association with frailty, physical function and cognition in community-dwelling older adults: findings from the HOPE Study. J. Nutr. Health Aging. 2021;25:679–687. doi: 10.1007/s12603-021-1625-3. - DOI - PubMed
    1. Wang Y, Ping Y-J, Jin H-Y, Ge N, Wu C. Prevalence and health correlates of anaemia among community-dwelling Chinese older adults: The China Health and Retirement Longitudinal Study. BMJ Open. 2020;10:e038147. doi: 10.1136/bmjopen-2020-038147. - DOI - PMC - PubMed
    1. Penninx BW, et al. Late-life anemia is associated with increased risk of recurrent falls. J. Am. Geriatr. Soc. 2005;53:2106–2111. doi: 10.1111/j.1532-5415.2005.00491.x. - DOI - PubMed