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Review
. 2024 Nov;291(21):4660-4669.
doi: 10.1111/febs.17103. Epub 2024 Feb 27.

Mitochondrial derived vesicles- Quo Vadis?

Reut Hazan Ben-Menachem  1 , Ophry Pines  1 , Ann Saada  2   3   4
Affiliations
Review

Mitochondrial derived vesicles- Quo Vadis?

Reut Hazan Ben-Menachem et al. FEBS J. 2024 Nov.

Abstract

Mitochondria are dynamic, intracellular organelles with a separate genome originating from prokaryotes. They perform numerous functions essential for cellular metabolism and energy production. Mitochondrial-derived vesicles (MDVs) are single or double membrane-enclosed vesicles, formed and released from the mitochondrial sub-compartments into the cytosol, in response to various triggers. MDVs interact with other organelles such as lysosomes and peroxisomes or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse protein and lipid cargoes and are involved in various functions such as mitochondrial quality control, immunomodulation, energy complementation, and compartmentalization and transport. This review aims to provide a summary of the current knowledge of MDVs biogenesis, release, cargoes, and roles.

Keywords: membrane; mitochondria; mitochondrial‐derived vesicles.

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