Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 13:11:1235335.
doi: 10.3389/fmed.2024.1235335. eCollection 2024.

Preliminary investigation of the effect of non-cardiac surgery on intraoperative islet and renal function: a single-center prospective cohort study

Yongtao Sun  1 , Xiaoning Zhang  1 , Min Zhang  1 , Yongle Guo  1   2 , Tao Sun  3 , Mengjie Liu  1 , Xiaojun Gao  1 , Yang Liu  1 , Zhongquan Gao  1   2 , Lina Chen  1 , Xiaoyan Du  4 , Yuelan Wang  2   5
Affiliations

Preliminary investigation of the effect of non-cardiac surgery on intraoperative islet and renal function: a single-center prospective cohort study

Yongtao Sun et al. Front Med (Lausanne). .

Abstract

Background: The effect of different non-cardiac surgical methods on islet and renal function remains unclear. We conducted a preliminary investigation to determine whether different surgical methods affect islet function or cause further damage to renal function.

Methods: In this prospective cohort study, the clinical data of 63 adult patients who underwent non-cardiac surgery under general anesthesia were evaluated from February 2019 to January 2020. Patients were divided into the abdominal surgery group, the laparoscopic surgery group, and the breast cancer surgery group. The primary outcome was the difference between the effects of different surgical methods on renal function.

Results: Islet and renal function were not significantly different between the groups. The correlation analysis showed that hematocrit (HCT) and hemoglobin (HB) were negatively correlated with fasting plasma glucose (FPG) (p < 0.05), MAP was positively correlated with C-peptide (p < 0.05), and HCT and Hb were positively correlated with serum creatinine (SCr) (p < 0.05). Fasting insulin (FINS) and C-peptide were negatively correlated with SCr (p < 0.05), and the homeostatic model assessment of insulin resistance (HOMA-IR) was positively correlated with SCr (p < 0.05). FINS, C-peptide, HOMA-IR, and the homeostatic model assessment of β-cell function (HOMA-β) were positively correlated with cystatin C (Cys C) (p < 0.05).

Conclusion: FINS, C-peptide, and HOMA-IR had positive effects on beta-2-microglobulin (β2-MG). FINS, C-peptide, and HOMA-IR were positively correlated with Cys C and β2-Mg. While FINS and C-peptide were negatively correlated with SCr, HOMA-IR was positively correlated with SCr.

Keywords: different operation methods; intraoperative; islet function; non-cardiac surgery; renal function.

PubMed Disclaimer

Conflict of interest statement

XD was employed by Yidu Cloud (Beijing) Technology Co. Ltd., Beijing, China. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
CONSORT flow diagram.
Figure 2
Figure 2
Trend chart of islet function. All data are presented as the mean ± SEM.
Figure 3
Figure 3
Trend chart of renal function. All data are presented as the mean ± SEM.
Figure 4
Figure 4
Trend chart of islet function. All data are presented as the mean ± SEM.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Reudink M, Huisman DE, van Rooijen SJ, Lieverse AG, Kroon HM, Roumen RMH, et al. . Association between intraoperative blood glucose and anastomotic leakage in colorectal surgery. J Gastrointest Surg. (2021) 25:2619–27. doi: 10.1007/s11605-021-04933-2, PMID: - DOI - PubMed
    1. Farahani F, Mirzaei F, Khodadadi I, Abbasi-Oshaghi E. Importance of hyperglycemia in preoperative, intraoperative and postoperative periods in COVID-19 patients. Int J Surg. (2020) 83:1–2. doi: 10.1016/j.ijsu.2020.08.048, PMID: - DOI - PMC - PubMed
    1. Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet. (2009) 373:1798–807. doi: 10.1016/s0140-6736(09)60553-5, PMID: - DOI - PMC - PubMed
    1. Roca-Ho H, Palau V, Gimeno J, Pascual J, Soler MJ, Riera M. Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice. Lab Investig. (2020) 100:1169–83. doi: 10.1038/s41374-020-0440-5, PMID: - DOI - PubMed
    1. Cheng Q, Leung PS. An update on the islet renin-angiotensin system. Peptides. (2011) 32:1087–95. doi: 10.1016/j.peptides.2011.03.003, PMID: - DOI - PubMed