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Case Reports
. 2024 Feb 23:18:503-506.
doi: 10.2147/PPA.S451007. eCollection 2024.

Real-Time Experience of Abrocitinib for the Treatment of Mucous Membrane Pemphigoid: A Case Report

Yan Teng  1 , Mingyang Ren  1 , Xianhong Yang  1 , Wei Lu  1 , Xiaohua Tao  1
Affiliations
Case Reports

Real-Time Experience of Abrocitinib for the Treatment of Mucous Membrane Pemphigoid: A Case Report

Yan Teng et al. Patient Prefer Adherence. .

Abstract

Background: Mucous membrane pemphigoid (MMP), a rare autoimmune vesiculous and erosive disorder, may affect multiple mucous membranes, with the oral cavity being the most commonly affected site. Its treatment depends on the site(s) of mucosal involvement and disease severity.

Patients and methods: A 62-year-old female patient with MMP that predominantly involved the oral cavity strongly rejected systemic corticosteroid or immunosuppressive agents and was successfully treated with abrocitinib, a highly selective JAK-1 inhibitor with a good safety profile.

Results: The case demonstrated good efficacy and safety profile of abrocitinib for the treatment of MMP with predominant oral involvement.

Conclusion: Abrocitinib is a promising agent for the treatment of MMP with oral involvement.

Keywords: JAK inhibitor; abrocitinib; mucous membrane pemphigoid.

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Conflict of interest statement

The authors declare that they have no conflicts of interest and no payment for expert testimony for this work.

Figures

Figure 1
Figure 1
Mucous membrane pemphigoid with the oral predominant response to abrocitinib therapy. (a) before the abrocitinib therapy. (b) Two weeks later after the abrocitinib therapy. (c) Four weeks later after the abrocitinib therapy.
Figure 2
Figure 2
(a) A cleavage between the epidermis and dermis with a few infiltrations of eosinophils and lymphocytes. (b) Direct immunofluorescence showed IgG was deposited linearly in the basement membrane zone.
See this image and copyright information in PMC

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