Evaluation of immuno-histochemical markers in oral squamous cell carcinoma

Yadavalli Guruprasad¹, Priya Singhal², Neha Gupta³, Bhavna Jha Kukreja⁴, Bharti Gupta⁵, Pankaj Kukreja⁶, Ramanpal Singh Makkad⁷, Dhaval Niranjan Mehta⁸

Affiliations

¹ Department of Dentistry, Vijaynagar Institute of Medical Sciences, VIMS Campus, Cantonment, Ballari - 583104, India.
² Senior Resident, Department of Dentistry, SMS Medical College, Jaipur, India.
³ Department of Oral Pathology, Microbiology and Forensic Odontology, Dental Institute, Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India.
⁴ Periodontology Preventive Dental sciences Department College of Dentistry, Gulf Medical University, Ajman UAE.
⁵ Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.
⁶ Oral and Maxillofacial Surgery, Department of Biomedical and Dental Sciences, Faculty of Dentistry, Al Baha University, Al Aqiq Campus, Kingdom of Saudi Arabia.
⁷ Department of Oral medicine and Radiology, New Horizon Dental College and Research, Institute, Sakri, Bilaspur, Chhattisgarh, India.
⁸ Department of Oral Medicine and Radiology, Narsinbhai Patel Dental college and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India.

PMID: 38415034
PMCID: PMC10895524
DOI: 10.6026/973206300191399

Evaluation of immuno-histochemical markers in oral squamous cell carcinoma

Yadavalli Guruprasad et al. Bioinformation. 2023.

. 2023 Dec 31;19(13):1399-1404.

doi: 10.6026/973206300191399. eCollection 2023.

Authors

Yadavalli Guruprasad¹, Priya Singhal², Neha Gupta³, Bhavna Jha Kukreja⁴, Bharti Gupta⁵, Pankaj Kukreja⁶, Ramanpal Singh Makkad⁷, Dhaval Niranjan Mehta⁸

Affiliations

¹ Department of Dentistry, Vijaynagar Institute of Medical Sciences, VIMS Campus, Cantonment, Ballari - 583104, India.
² Senior Resident, Department of Dentistry, SMS Medical College, Jaipur, India.
³ Department of Oral Pathology, Microbiology and Forensic Odontology, Dental Institute, Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India.
⁴ Periodontology Preventive Dental sciences Department College of Dentistry, Gulf Medical University, Ajman UAE.
⁵ Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.
⁶ Oral and Maxillofacial Surgery, Department of Biomedical and Dental Sciences, Faculty of Dentistry, Al Baha University, Al Aqiq Campus, Kingdom of Saudi Arabia.
⁷ Department of Oral medicine and Radiology, New Horizon Dental College and Research, Institute, Sakri, Bilaspur, Chhattisgarh, India.
⁸ Department of Oral Medicine and Radiology, Narsinbhai Patel Dental college and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India.

PMID: 38415034
PMCID: PMC10895524
DOI: 10.6026/973206300191399

Abstract

Evaluation of immuno-histochemical (IHC) markers like p53, p63, PDPN, C-erb-B2, CK19, and VEGF in oral squamous cell carcinoma (OSCCs) is of interest to dentists. Sixty formalin-fixed paraffin embedded tissue blocks from the Department of Oral Pathology, New Horizon Dental College and Research, Institute, Sakri, Bilaspur, Chhattisgarh, India. The conventional IHC method was used to assess the expression of p53, p63, PDPN, C- erb-B2, CK19 and VEGF using the different antibodies. Data shows that P53, p63 had high values of labeling index (LI) of staining while PDPN, C-erb-B2 had low values of LI of staining. The values of LI of staining for CK19, and VEGF were in between the two types of IHCs. Combining the analysis of multiple IHC markers for OSCC can yield precise cancer diagnosis results.

Keywords: Immunohistochemistry; markers; oral squamous cell carcinoma.

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Correlation of Histological Grading with Regional Metastasis in Oral Squamous Cell Carcinoma - A Cross-Sectional Study.
Patel R, Patel K, Mehta R, Babel A, Nandini C, Chaudhari MA, Mehta DN. Patel R, et al. J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S764-S766. doi: 10.4103/jpbs.jpbs_170_25. Epub 2025 Apr 9. J Pharm Bioallied Sci. 2025. PMID: 40511240 Free PMC article.

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Evaluation of immuno-histochemical markers in oral squamous cell carcinoma

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Evaluation of immuno-histochemical markers in oral squamous cell carcinoma

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