Advanced Targeted Drug Delivery of Bioactive Agents Fortified with Graft Chitosan in Management of Cancer: A Review

Abstract

Cancer is characterized by the uncontrolled proliferation and spread of abnormal cells in the body, resulting in the development of tumors or clusters of irregular cells. The factors contributing to cancer are intricate, involving a combination of genetic, environmental, and lifestyle elements. Risk factors for cancer include the use of nicotine, excessive alcohol consumption, exposure to radiation or specific chemicals, and a family history of the disease. Common treatment methods for cancer encompass surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy. These treatments aim to eliminate cancer cells while minimizing harm to healthy cells. Recent research has extensively explored the potential of bioactive compounds as agents for combating cancer. However, effectively delivering such compounds to specific target sites is a complex undertaking. Consequently, there has been widespread exploration of polymer applications in the development of nanomedicine for delivering bioactive substances. Additionally, the technique of grafting native excipients onto polymers has been investigated to enhance their versatility in the delivery of these compounds to specific tumor cells. This review offers a brief yet informative summary of how grafted chitosan is employed as a delivery system for bioactive phytopharmaceuticals possessing anticancer properties. In essence, it delves into the use of grafted chitosan in facilitating the transport and targeted release of these natural compounds that have demonstrated potential in combating cancer. This innovative approach has the potential to enhance the effectiveness of anticancer treatments and minimize their adverse effects on healthy cells.

Keywords: Cancer; graft chitosan; grafted excipients; nanomedicine; radiation therapy.; targeted drug delivery.