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. 2024 Feb 1;25(2):603-608.
doi: 10.31557/APJCP.2024.25.2.603.

High Expression of PXMP4 in Hepatocellular Carcinoma Tissues

Ming Ming Zhao  1 , Zarina Awang  1 , Farra Aidah Binti Jumuddin  1
Affiliations

High Expression of PXMP4 in Hepatocellular Carcinoma Tissues

Ming Ming Zhao et al. Asian Pac J Cancer Prev. .

Abstract

Objective: To analyze the high expression of peroxisome membrane protein 4 (PXMP4) in hepatocellular carcinoma (HCC) and its clinical significance.

Methods: The expression of PXMP4 mRNA in HCC tissues and corresponding adjacent tissues was detected by Q-PCR, and the expression of PXMP4 protein was detected by Western blot and immunohistochemistry. The correlation of PXMP4 protein expression with clinicopathological features and prognosis of HCC was analyzed.

Results: The expression levels of PXMP4 mRNA and protein in HCC tissues were significantly higher than those in adjacent tissues (P < 0.05), and its high expression was significantly correlated with tumor differentiation, lymph node metastasis, depth of invasion and TNM stage (P < 0.05). Patients with high expression of PXMP4 had a poor prognosis (P < 0.05).

Conclusion: The high expression of PXMP4 may promote the occurrence and development of HCC, and inhibition of PXMP4 may be one of the potential molecular targets for targeted therapy of HCC.

Keywords: Keywords: Hepatocellular Carcinoma; PXMP4; Prognosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
. Detect the PXMP4 Protein Expression in Hepatocellular Carcinoma and Its Adjacent Tissues by Western Blot
Figure 2
Figure 2
Detect the Expression of PXMP4 in Rectal Adenocarcinoma by Immunohistochemistry
Figure 3
Figure 3
Survival Curve of Kaplan-Meier in Patients with Hepatocellular Carcinoma
See this image and copyright information in PMC

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