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. 2024 Apr 3;68(4):e0154823.
doi: 10.1128/aac.01548-23. Epub 2024 Feb 28.

Effect of modification of penicillin-binding protein 3 on susceptibility to ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam, aztreonam-avibactam, cefepime-taniborbactam, and cefiderocol of Escherichia coli strains producing broad-spectrum β-lactamases

Christophe Le Terrier  1   2 , Patrice Nordmann  1   3 , Chloé Buchs  1 , Laurent Poirel  1   3
Affiliations

Effect of modification of penicillin-binding protein 3 on susceptibility to ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam, aztreonam-avibactam, cefepime-taniborbactam, and cefiderocol of Escherichia coli strains producing broad-spectrum β-lactamases

Christophe Le Terrier et al. Antimicrob Agents Chemother. .

Abstract

The impact of penicillin-binding protein 3 (PBP3) modifications that may be identified in Escherichia coli was evaluated with respect to susceptibility to β-lactam/β-lactamase inhibitor combinations including ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam, aztreonam-avibactam, cefepime-taniborbactam, and to cefiderocol. A large series of E. coli recombinant strains producing broad-spectrum β-lactamases was evaluated. While imipenem-relebactam showed a similar activity regardless of the PBP3 background, susceptibility to other molecules tested was affected at various levels. This was particularly the case for ceftazidime-avibactam, aztreonam-avibactam, and cefepime-taniborbactam.

Keywords: PBP3; YRIK; YRIN; avibactam; cefiderocol; relebactam; susceptibility testing; taniborbactam; vaborbactam; β-lactamase.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Blair JMA, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJV. 2015. Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol 13:42–51. doi:10.1038/nrmicro3380 - DOI - PubMed
    1. Karlowsky JA, Hackel MA, Wise MG, Six DA, Uehara T, Daigle DM, Cusick SM, Pevear DC, Moeck G, Sahm DF. 2023. In vitro activity of cefepime-taniborbactam and comparators against clinical isolates of Gram-negative bacilli from 2018 to 2020: results from the global evaluation of antimicrobial resistance via surveillance (GEARS) program. Antimicrob Agents Chemother 67:e0128122. doi:10.1128/aac.01281-22 - DOI - PMC - PubMed
    1. Hernández-García M, García-Castillo M, Ruiz-Garbajosa P, Bou G, Siller-Ruiz M, Pitart C, Gracia-Ahufinger I, Mulet X, Pascual Á, Tormo N, Cantón R. 2022. In vitro activity of cefepime-taniborbactam against carbapenemase-producing Enterobacterales and Pseudomonas aeruginosa isolates recovered in Spain. Antimicrob Agents Chemother 66:e0216121. doi:10.1128/aac.02161-21 - DOI - PMC - PubMed
    1. Le Terrier C, Freire S, Nordmann P, Poirel L. 2024. Multidrug-resistant Gram-negative clinical isolates with reduced susceptibility/resistance to cefiderocol: which are the best present and future therapeutic alternatives? Eur J Clin Microbiol Infect Dis 43:339–354. doi:10.1007/s10096-023-04732-4 - DOI - PMC - PubMed
    1. Nordmann P, Poirel L. 2019. Epidemiology and diagnostics of carbapenem resistance in Gram-negative bacteria. Clin Infect Dis 69:S521–S528. doi:10.1093/cid/ciz824 - DOI - PMC - PubMed

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