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. 2024 Feb 28;32(3):198.
doi: 10.1007/s00520-024-08395-5.

Feasibility and acceptability of C-PRIME: A health promotion intervention for family caregivers of patients with colorectal cancer

Lisa M Gudenkauf  1 , Xiaoyin Li  2 , Aasha I Hoogland  2 , Laura B Oswald  2 , Iman Lmanirad  3 , Jennifer B Permuth  3   4 , Brent J Small  5 , Heather S L Jim  2 , Yvelise Rodriguez  2 , Crystal A Bryant  2 , Kellie N Zambrano  2 , Kerie O Walters  2 , Maija Reblin  6 , Brian D Gonzalez  2
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Feasibility and acceptability of C-PRIME: A health promotion intervention for family caregivers of patients with colorectal cancer

Lisa M Gudenkauf et al. Support Care Cancer. .

Abstract

Purpose: This study aimed to test the feasibility and acceptability of a digital health promotion intervention for family caregivers of patients with advanced colorectal cancer and explore the intervention's preliminary efficacy for mitigating the impact of caregiving on health and well-being.

Methods: We conducted a single-arm pilot feasibility trial of C-PRIME (Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life), an 8-week digital health-promotion behavioral intervention involving monitoring and visualizing health-promoting behaviors (e.g., objective sleep and physical activity data) and health coaching (NCT05379933). A priori benchmarks were established for feasibility (≥ 50% recruitment and objective data collection; ≥ 75% session engagement, measure completion, and retention) and patient satisfaction (> 3 on a 1-5 scale). Preliminary efficacy was explored with pre- to post-intervention changes in quality of life (QOL), sleep quality, social engagement, and self-efficacy.

Results: Participants (N = 13) were M = 52 years old (SD = 14). Rates of recruitment (72%), session attendance (87%), assessment completion (87%), objective data collection (80%), and retention (100%) all indicated feasibility. All participants rated the intervention as acceptable (M = 4.7; SD = 0.8). Most participants showed improvement or maintenance of QOL (15% and 62%), sleep quality (23% and 62%), social engagement (23% and 69%), and general self-efficacy (23% and 62%).

Conclusion: The C-PRIME digital health promotion intervention demonstrated feasibility and acceptability among family caregivers of patients with advanced colorectal cancer. A fully powered randomized controlled trial is needed to test C-PRIME efficacy, mechanisms, and implementation outcomes, barriers, and facilitators in a divserse sample of family caregivers.

Trial registration: The Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life (C-PRIME) study was registered on clinicaltrials.gov, NCT05379933, in May 2022.

Keywords: Acceptability; Behavioral intervention; Colorectal cancer; Digital health; Family caregivers; Feasibility.

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