Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb 28;13(Supplement_1):S22-S30.
doi: 10.1093/jpids/piae005.

Cytomegalovirus Cell-mediated Immunity Assays in Pediatric Transplantation

William R Otto  1   2 , Surabhi B Vora  3   4 , Daniel E Dulek  5   6
Affiliations
Review

Cytomegalovirus Cell-mediated Immunity Assays in Pediatric Transplantation

William R Otto et al. J Pediatric Infect Dis Soc. .

Abstract

Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in pediatric transplantation. However, currently utilized CMV prevention paradigms have limitations, leading to research aimed at novel strategies for mitigation of CMV infection. Cell-mediated immunity (CMI) is crucial in controlling CMV infection and the use of CMV-specific CMI assays to guide prevention and treatment of CMV infection in both solid organ transplant and hematopoietic cell transplant recipients shows great promise. In this article, we review the immune response to CMV infection to highlight the rationale for CMI assays, describe available commercial assays and strategies for their use, and summarize relevant literature regarding the use of CMI assays in transplant recipients.

Keywords: cell-mediated immunity; children; cytomegalovirus; hematopoietic cell transplantation; solid organ transplantation.

PubMed Disclaimer

Substances