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Randomized Controlled Trial
. 2024 Jun;90(6):585-593.
doi: 10.1111/cod.14532. Epub 2024 Feb 28.

Introducing the model of repeated exposure of skin to antiseptics: Randomised pilot trial

Dario Leskur  1 , Ivana Bročić  1 , Mislav Mićanović  1 , Mirela Lozić  2 , Doris Rušić  1 , Ana Šešelja Perišin  1 , Ivanka Maleš  1 , Darko Modun  1 , Josipa Bukić  1
Affiliations
Randomized Controlled Trial

Introducing the model of repeated exposure of skin to antiseptics: Randomised pilot trial

Dario Leskur et al. Contact Dermatitis. 2024 Jun.

Abstract

Introduction: Intensified hand hygiene measures were recommended for preventing the spread of SARS-CoV-2. However, these measures can lead to skin damage and the development of hand eczema, particularly among health professionals.

Objectives: This pilot study aimed to evaluate the effects of repeated antiseptic use on healthy skin under controlled conditions and to assess the emollient use.

Methods: Twelve healthy volunteers (nine females, age = 22.3 ± 2.8 years (mean ± SD), Fitzpatrick phototypes II and III) with no skin diseases were recruited. Antiseptic was applied daily for 3 weeks on the volar sides of forearms. Emollient cream was also applied daily. Skin assessments were performed using non-invasive methods (transepidermal water loss-TEWL, skin hydration, erythema and melanin content).

Results: Prolonged antiseptic use increased TEWL, decreased hydration and elevated erythema and melanin levels. Emollient cream significantly reduced TEWL and improved hydration on antiseptic-treated sites, and also enhanced hydration on intact skin.

Conclusions: Prolonged use of antiseptics can have adverse effects on the skin, including barrier disruption and inflammation. Emollient showed promise in improving skin hydration and reducing the damage caused by antiseptics. Further research with a larger sample is needed to confirm these findings and assess emollient efficacy during frequent antiseptic use.

Keywords: TEWL; antiseptic; emollient cream; erythema; human in vivo skin damage model; hydration; non‐invasive methods.

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References

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