Analysis of Factors Related to Gastroesophageal Reflux After Gastric Bypass at 10-Year Follow-up: A Retrospective Single-institutional Study

doi:10.21873/invivo.13531

. 2024 Mar-Apr;38(2):982-989.

doi: 10.21873/invivo.13531.

Analysis of Factors Related to Gastroesophageal Reflux After Gastric Bypass at 10-Year Follow-up: A Retrospective Single-institutional Study

Niccolò Petrucciani¹, Marine Benois², Paolo Aurello³, Hubert Boudrie⁴, Olivier VAN Haverbeke⁴, Sara Claudia Barone³, Francesco Martini⁴, Arnaud Liagre⁴

Affiliations

¹ Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, St Andrea Hospital, Sapienza University, Rome, Italy; niccolo.petrucciani@uniroma1.it.
² Department of Digestive Surgery, CHU Félix Guyon, Saint-Denis, France.
³ Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, St Andrea Hospital, Sapienza University, Rome, Italy.
⁴ Clinique des Cedres, Bariatric Surgery Unit, Ramsay Générale de Santé, Cornebarrieu, France.

PMID: 38418102
PMCID: PMC10905459
DOI: 10.21873/invivo.13531

Analysis of Factors Related to Gastroesophageal Reflux After Gastric Bypass at 10-Year Follow-up: A Retrospective Single-institutional Study

Niccolò Petrucciani et al. In Vivo. 2024 Mar-Apr.

. 2024 Mar-Apr;38(2):982-989.

doi: 10.21873/invivo.13531.

Authors

Niccolò Petrucciani¹, Marine Benois², Paolo Aurello³, Hubert Boudrie⁴, Olivier VAN Haverbeke⁴, Sara Claudia Barone³, Francesco Martini⁴, Arnaud Liagre⁴

Affiliations

¹ Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, St Andrea Hospital, Sapienza University, Rome, Italy; niccolo.petrucciani@uniroma1.it.
² Department of Digestive Surgery, CHU Félix Guyon, Saint-Denis, France.
³ Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, St Andrea Hospital, Sapienza University, Rome, Italy.
⁴ Clinique des Cedres, Bariatric Surgery Unit, Ramsay Générale de Santé, Cornebarrieu, France.

PMID: 38418102
PMCID: PMC10905459
DOI: 10.21873/invivo.13531

Abstract

Background/aim: Long-term gastroesophageal reflux (GERD) after gastric bypass for obesity is underestimated. The present study aimed to evaluate the rate of treated GERD and the factors influencing it in a cohort of patients who underwent gastric bypass.

Patients and methods: Patients who underwent one-anastomosis gastric bypass (OAGB) or Roux-en-Y gastric bypass (RYGB) as a primary bariatric procedure between 2010 and 2011 at a French private referral center were included in the study. The primary endpoint was the 10-year prevalence of GERD.

Results: In total, 422 patients underwent RYGB and 334 underwent OAGB with a biliopancreatic limb of 150 cm. The mean age was 38.9±11.3 years, and 81.6% of patients were female; the mean preoperative body mass index was 42.8±5 kg/m² Preoperative GERD was diagnosed in 40.8% of patients in the total cohort, 31.7% in the RYGB group versus 49.1% in the OAGB group (p<0.0001). At 10-year follow-up, the rate of GERD was 21.1%, with no difference between the two groups. Remission of preoperative GERD and de novo GERD were comparable between the two types of bypass. Surgery for GERD resistant to medical treatment was more frequent in the OAGB group. At multivariate analysis, factors significantly correlated with long-term GERD were: Preoperative GERD, total weight loss at 120 months <25%, glycemic imbalances and anastomotic ulcers.

Conclusion: Identification and correction of modifiable factors may help reduce the incidence of long-term GERD.

Keywords: Bariatric surgery; Roux-en-Y gastric bypass; gastroesophageal reflux; long-term outcomes; obesity; reflux; single-anastomosis gastric bypass.

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Conflict of interest statement

The Authors have no conflicts of interest to disclose. They declare that there are no financial or personal relationships that could inappropriately bias the work. No funding was received for the present study.

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1. Kothari SN, Borgert AJ, Kallies KJ, Baker MT, Grover BT. Long-term (>10-year) outcomes after laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2017;13(6):972–978. doi: 10.1016/j.soard.2016.12.011. - DOI - PubMed
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[1] Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, Bengtsson C, Dahlgren S, Gummesson A, Jacobson P, Karlsson J, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Agren G, Carlsson LM, Swedish Obese Subjects Study Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–752. doi: 10.1056/NEJMoa066254. - DOI - PubMed

[2] Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, Bengtsson C, Dahlgren S, Gummesson A, Jacobson P, Karlsson J, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Agren G, Carlsson LM, Swedish Obese Subjects Study Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–752. doi: 10.1056/NEJMoa066254. - DOI - PubMed

[3] Liagre A, Benois M, Queralto M, Boudrie H, Van Haverbeke O, Juglard G, Martini F, Petrucciani N. Ten-year outcome of one-anastomosis gastric bypass with a biliopancreatic limb of 150 cm versus Roux-en-Y gastric bypass: a single-institution series of 940 patients. Surg Obes Relat Dis. 2022;18(10):1228–1238. doi: 10.1016/j.soard.2022.05.021. - DOI - PubMed

[4] Liagre A, Benois M, Queralto M, Boudrie H, Van Haverbeke O, Juglard G, Martini F, Petrucciani N. Ten-year outcome of one-anastomosis gastric bypass with a biliopancreatic limb of 150 cm versus Roux-en-Y gastric bypass: a single-institution series of 940 patients. Surg Obes Relat Dis. 2022;18(10):1228–1238. doi: 10.1016/j.soard.2022.05.021. - DOI - PubMed

[5] Carandina S, Soprani A, Zulian V, Cady J. Long-term results of one anastomosis gastric bypass: a single center experience with a minimum follow-up of 10 years. Obes Surg. 2021;31(8):3468–3475. doi: 10.1007/s11695-021-05455-1. - DOI - PubMed

[6] Carandina S, Soprani A, Zulian V, Cady J. Long-term results of one anastomosis gastric bypass: a single center experience with a minimum follow-up of 10 years. Obes Surg. 2021;31(8):3468–3475. doi: 10.1007/s11695-021-05455-1. - DOI - PubMed

[7] Kothari SN, Borgert AJ, Kallies KJ, Baker MT, Grover BT. Long-term (>10-year) outcomes after laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2017;13(6):972–978. doi: 10.1016/j.soard.2016.12.011. - DOI - PubMed

[8] Kothari SN, Borgert AJ, Kallies KJ, Baker MT, Grover BT. Long-term (>10-year) outcomes after laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2017;13(6):972–978. doi: 10.1016/j.soard.2016.12.011. - DOI - PubMed

[9] Obeid NR, Malick W, Concors SJ, Fielding GA, Kurian MS, Ren-Fielding CJ. Long-term outcomes after Roux-en-Y gastric bypass: 10- to 13-year data. Surg Obes Relat Dis. 2016;12(1):11–20. doi: 10.1016/j.soard.2015.04.011. - DOI - PubMed

[10] Obeid NR, Malick W, Concors SJ, Fielding GA, Kurian MS, Ren-Fielding CJ. Long-term outcomes after Roux-en-Y gastric bypass: 10- to 13-year data. Surg Obes Relat Dis. 2016;12(1):11–20. doi: 10.1016/j.soard.2015.04.011. - DOI - PubMed

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Analysis of Factors Related to Gastroesophageal Reflux After Gastric Bypass at 10-Year Follow-up: A Retrospective Single-institutional Study

Affiliations

Analysis of Factors Related to Gastroesophageal Reflux After Gastric Bypass at 10-Year Follow-up: A Retrospective Single-institutional Study

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