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. 2024 Feb 28;14(1):4848.
doi: 10.1038/s41598-024-55475-x.

LDCT screening results among eligible and ineligible screening candidates in preventive health check-ups population: a real world study in West China

Ting Bao  1   2 , Bingqing Liu  3 , Ruicen Li  1 , Zhenzhen Li  1 , Guiyi Ji  1 , Youjuan Wang  1 , Hanwei Yang  1 , Weimin Li  4 , Wenxia Huang  5 , Yan Huang  6 , Huairong Tang  7
Affiliations

LDCT screening results among eligible and ineligible screening candidates in preventive health check-ups population: a real world study in West China

Ting Bao et al. Sci Rep. .

Abstract

To compare the LDCT screening results between eligible and ineligible screening candidates in preventive health check-ups population. Using a real-world LDCT screening results among people who took yearly health check-up in health management center of West China Hospital between 2006 and 2017. Objects were classified according to the China National Lung Cancer Screening Guideline with Low-dose Computed Tomography (2018 version) eligibility criteria. Descriptive analysis were performed between eligible and ineligible screening candidates. The proportion of ineligible screening candidates was 64.13% (10,259), and among them there were 4005 (39.04%) subjects with positive screenings, 80 cases had a surgical lung biopsy. Pathology results from lung biopsy revealed 154 cancers (true-positive) and 26 benign results (false-positive), the surgical false-positive biopsy rate was 4.17%, and ineligible group (7.69%) was higher than eligible group (2.47%), P < 0.05. Further, in ineligible screening candidates, the proportion of current smokers was higher among males compared to females (53.85% vs. 4.88%, P < 0.05). Of the 69 lung cancer patients detected in ineligible screening candidates, lung adenocarcinoma accounts for a high proportion of lung cancers both in male (75.00%) and female (85.00%). The proportion of ineligible screening candidates and the surgical false-positive biopsy rate in ineligible candidates were both high in health check-ups population.

Keywords: False-positive biopsy; Ineligible screening candidates; Low-dose spiral CT; Lung cancer screening.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Gender, age and smoking status characteristics of lung cancer detected.
Figure 2
Figure 2
The pathological classification and stage of lung cancer.
Figure 3
Figure 3
Gender, and smoking status characteristics of pathological classification and stage of lung cancer in ineligible screening candidates.
Figure 4
Figure 4
Study flow diagram.
See this image and copyright information in PMC

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