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Randomized Controlled Trial
. 2024 Apr;34(4):1306-1315.
doi: 10.1007/s11695-024-07117-4. Epub 2024 Feb 28.

Effects of Probiotic Use on Gastrointestinal Symptoms in the Late Postoperative Period of Bariatric Surgery: A Cross-Over, Randomized, Triple-Blind, Placebo-Controlled Study

Nathalia Ramori Farinha Wagner  1   2 , Maria Clara Peixoto Lopes  3 , Ricardo Fernandes  4 , Cesar Augusto Taconelli  5 , Giovanna Mozzaquatro Nascimento  6 , Julia Pessini  6 , Erasmo Benicio Santos de Moraes Trindade  6 , Antonio Carlos Ligocki Campos  3
Affiliations
Randomized Controlled Trial

Effects of Probiotic Use on Gastrointestinal Symptoms in the Late Postoperative Period of Bariatric Surgery: A Cross-Over, Randomized, Triple-Blind, Placebo-Controlled Study

Nathalia Ramori Farinha Wagner et al. Obes Surg. 2024 Apr.

Abstract

Introduction: Despite the benefits associated with weight reduction, the anatomical and functional changes of bariatric surgery may favor the development of undesirable side effects such as the appearance of gastrointestinal symptoms (GIS). The aim of this study was to evaluate the effects of using probiotics in individuals with GIS 1 year after being submitted to Roux-en-Y Gastric Bypass (RYGB).

Materials and methods: This is an experimental, prospective, randomized, cross-over, triple-blind, placebo-controlled study, carried out with patients 1 year after being submitted to RYGB and who reported at least one moderate GIS. Subjects were randomized into two groups and completed the two research periods: in one they received placebo capsules, in the other 50 billion CFU of probiotics (Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus rhamnosus, Bifidobacterium longum, Lactobacillus plantarum, Bifidobacterium bifidum and Lactobacillus gasseri), both for 8 weeks, with 8 weeks of wash-out period in between, and were evaluated for the presence of Small Intestine Bacterial Overgrowth (SIBO) and GIS, through the Hydrogen breath test and Gastric Symptom Rating Scale (GSRS) questionnaire.

Results: Of a total of 56 participants, 47 individuals completed the study. No significant effects were observed in neither the gastrointestinal symptoms or in the prevalence of SIBO with the use of probiotics.

Conclusion: Supplementation of the probiotics chosen for this study does not seem to alleviate GIS or influence the improvement of SIBO in symptomatic patients after 1 year of RYGB.

Keywords: Bariatric surgery; Gastrointestinal symptoms; Probiotics.

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References

    1. Tremmel M, Gerdtham UG, Nilsson PM, Saha S. Economic burden of obesity: a systematic literature review. Int J Environ Res Public Health. 2017;14(4):435. https://doi.org/10.3390/ijerph14040435 . - DOI - PubMed - PMC
    1. Sociedade Brasileira de Cirurgia Bariátrica e Metabólica (sbcbm). Tratamento Cirúrgico: Técnicas Cirúrgicas, 2017. Portuguese. Available from: www.sbcbm.org.br/tecnicas-cirurgicas-bariatrica/
    1. Brown W, Shikora S, Liem R, Holland J, Campbell AB, Sprinkhuizen SM, et al. 7th IFSO global registry report. International federation for the surgery of obesity and metabolic disorders. 2022. Available from: https://www.ifso.com/pdf/ifso-7th-registry-report-2022.pdf .
    1. Høgestøl IK, Chahal-Kummen M, Eribe I, Brunborg C, Stubhaug A, Hewitt S, et al. Chronic abdominal pain and symptoms 5 years after gastric bypass for morbid obesity. Obes Surg. 2017;27(6):1438–45. https://doi.org/10.1007/s11695-016-2499-z . - DOI - PubMed
    1. Boerlage TCC, Westerink F, van de Laar AWJM, Hutten BA, Brandjes DPM, Gerdes VEA. Gastrointestinal symptoms before and after laparoscopic Roux-en-Y gastric bypass: a longitudinal assessment. Surg Obes Relat Dis. 2019;15(6):871–7. https://doi.org/10.1016/j.soard.2019.03.018 . - DOI - PubMed

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