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Review
. 2024 Feb 14:17:1327472.
doi: 10.3389/fnmol.2024.1327472. eCollection 2024.

Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives

Hao Dong  1 , Xin Wen  1 , Bai-Wen Zhang  1 , Zhe Wu  1 , Wei Zou  2
Affiliations
Review

Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives

Hao Dong et al. Front Mol Neurosci. .

Abstract

Intracerebral hemorrhage (ICH) manifests precipitously and profoundly impairs the neurological function in patients who are affected. The etiology of subsequent injury post-ICH is multifaceted, characterized by the intricate interplay of various factors, rendering therapeutic interventions challenging. Astrocytes, a distinct class of glial cells, interact with neurons and microglia, and are implicated in a series of pathophysiological alterations following ICH. A comprehensive examination of the functions and mechanisms associated with astrocytic proteins may shed light on the role of astrocytes in ICH pathology and proffer innovative therapeutic avenues for ICH management.

Keywords: astrocytes; crosstalk; inflammatory response; intracerebral hemorrhage; neurological function.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The peak-time of astrocyte proteins expression after intracerebral hemorrhage (by Figdraw.).
See this image and copyright information in PMC

References

    1. Ango F., Prézeau L., Muller T., Tu J. C., Xiao B., Worley P. F., et al. (2001). Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411, 962–965. 10.1038/35082096 - DOI - PubMed
    1. Baraban M., Koudelka S., Lyons D. A. (2018). Ca (2+) activity signatures of myelin sheath formation and growth in vivo. Nat. Neurosci. 21, 19–23. 10.1038/s41593-017-0040-x - DOI - PMC - PubMed
    1. Bordone M. P., Salman M. M., Titus H. E., Amini E., Andersen J. V., Chakraborti B., et al. (2019). The energetic brain–a review from students to students. J. Neurochem. 151, 139–165. 10.1111/jnc.14829 - DOI - PubMed
    1. Buscemi L., Ginet V., Lopatar J., Montana V., Pucci L., Spagnuolo P., et al. (2017). Homer1 scaffold proteins govern Ca2+ dynamics in normal and reactive astrocytes. Cereb Cortex 27, 2365–2384. 10.1093/cercor/bhw078 - DOI - PMC - PubMed
    1. Chen Z.-Q., Yu H., Li H. Y., Shen H.-T., Li X., Zhang J. Y., et al. (2019). Negative regulation of glial Tim-3 inhibits the secretion of inflammatory factors and modulates microglia to antiinflammatory phenotype after experimental intracerebral hemorrhage in rats. CNS Neurosci. Ther. 25, 674–684. 10.1111/cns.13100 - DOI - PMC - PubMed

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