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Review
. 2024 Feb 14:15:1279584.
doi: 10.3389/fphar.2024.1279584. eCollection 2024.

Shenfu injection: a review of pharmacological effects on cardiovascular diseases

Fei-Fei Xu  1   2 , Xiao-Fang Xie  1 , Hai-Yan Hu  3 , Rong-Sheng Tong  2 , Cheng Peng  1
Affiliations
Review

Shenfu injection: a review of pharmacological effects on cardiovascular diseases

Fei-Fei Xu et al. Front Pharmacol. .

Abstract

Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Shenfu Decoction created more than 700 years ago. SFI has been widely used in China for over 30 years for treating cardiovascular diseases. The main components in it include ginsenosides and aconitum alkaloids. In recent years, the role of SFI in the treatment of cardiovascular diseases has attracted much attention. The pharmacological effects and therapeutic applications of SFI in cardiovascular diseases are summarized here, highlighting pharmacological features and potential mechanisms developments, confirming that SFI can play a role in multiple ways and is a promising drug for treating cardiovascular diseases.

Keywords: Shenfu injection; TCM (traditional Chinese medicine); cardiovascular disease; clinical trial; heart failure; pharmacology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Shenfu injection.
FIGURE 2
FIGURE 2
Ginseng Radix et Rhizoma Rubra.
FIGURE 3
FIGURE 3
Aconiti lateralis radix praeparata.
FIGURE 4
FIGURE 4
Structural formula of ginsenoside Re.
FIGURE 5
FIGURE 5
Structural formula of ginsenoside Rg1.
FIGURE 6
FIGURE 6
Structural formula of ginsenoside Rg2.
FIGURE 7
FIGURE 7
Structural formula of ginsenoside Rb1.
FIGURE 8
FIGURE 8
Structural formula of ginsenoside Rd.
FIGURE 9
FIGURE 9
Structural formula of ginsenoside Rh2.
FIGURE 10
FIGURE 10
Structural formula of ginsenoside Rc.
FIGURE 11
FIGURE 11
Structural formula of benzoylmesaconine.
FIGURE 12
FIGURE 12
Structural formula of aconitine.
FIGURE 13
FIGURE 13
The pharmacological effect of Shenfu injection (SFI) on cardiovascular diseases.
See this image and copyright information in PMC

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