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. 2024 Mar 19;60(24):3283-3286.
doi: 10.1039/d4cc00057a.

Asymmetric synthesis of enantioenriched α-allyl esters through Pd(BINAPHANE)-catalysed allylation of disubstituted ketenes

Ahmad A Ibrahim  1 , Stephen C J O'Reilly  2 , Margot Bottarel  2 , Nessan J Kerrigan  2
Affiliations

Asymmetric synthesis of enantioenriched α-allyl esters through Pd(BINAPHANE)-catalysed allylation of disubstituted ketenes

Ahmad A Ibrahim et al. Chem Commun (Camb). .

Abstract

Pd2dba3·CHCl3 (2.5 mol%)-BINAPHANE (5 mol%) was used to promote the first catalytic enantioselective allylation of disubstituted ketenes to give α-allyl esters. The ester products were formed in good to excellent yields (61-93% yield for 13 examples, 16 examples in all), with moderate to good enantioselectivity (68-80% ee for 7 examples).

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