Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 29;73(8):180-188.
doi: 10.15585/mmwr.mm7308a5.

Interim Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged ≥18 Years - VISION and IVY Networks, September 2023-January 2024

Jennifer DeCuir, Amanda B Payne, Wesley H Self, Elizabeth A K Rowley, Kristin Dascomb, Malini B DeSilva, Stephanie A Irving, Shaun J Grannis, Toan C Ong, Nicola P Klein, Zachary A Weber, Sarah E Reese, Sarah W Ball, Michelle A Barron, Allison L Naleway, Brian E Dixon, Inih Essien, Daniel Bride, Karthik Natarajan, Bruce Fireman, Ami B Shah, Erica Okwuazi, Ryan Wiegand, Yuwei Zhu, Adam S Lauring, Emily T Martin, Manjusha Gaglani, Ithan D Peltan, Samuel M Brown, Adit A Ginde, Nicholas M Mohr, Kevin W Gibbs, David N Hager, Matthew Prekker, Amira Mohamed, Vasisht Srinivasan, Jay S Steingrub, Akram Khan, Laurence W Busse, Abhijit Duggal, Jennifer G Wilson, Steven Y Chang, Christopher Mallow, Jennie H Kwon, Matthew C Exline, Cristie Columbus, Ivana A Vaughn, Basmah Safdar, Jarrod M Mosier, Estelle S Harris, Jonathan D Casey, James D Chappell, Carlos G Grijalva, Sydney A Swan, Cassandra Johnson, Nathaniel M Lewis, Sascha Ellington, Katherine Adams, Mark W Tenforde, Clinton R Paden, Fatimah S Dawood, Katherine E Fleming-Dutra, Diya Surie, Ruth Link-Gelles; CDC COVID-19 Vaccine Effectiveness Collaborators
Collaborators, Affiliations

Interim Effectiveness of Updated 2023-2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged ≥18 Years - VISION and IVY Networks, September 2023-January 2024

Jennifer DeCuir et al. MMWR Morb Mortal Wkly Rep. .

Abstract

In September 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (monovalent XBB.1.5) COVID-19 vaccination for all persons aged ≥6 months to prevent COVID-19, including severe disease. However, few estimates of updated vaccine effectiveness (VE) against medically attended illness are available. This analysis evaluated VE of an updated COVID-19 vaccine dose against COVID-19-associated emergency department (ED) or urgent care (UC) encounters and hospitalization among immunocompetent adults aged ≥18 years during September 2023-January 2024 using a test-negative, case-control design with data from two CDC VE networks. VE against COVID-19-associated ED/UC encounters was 51% (95% CI = 47%-54%) during the first 7-59 days after an updated dose and 39% (95% CI = 33%-45%) during the 60-119 days after an updated dose. VE estimates against COVID-19-associated hospitalization from two CDC VE networks were 52% (95% CI = 47%-57%) and 43% (95% CI = 27%-56%), with a median interval from updated dose of 42 and 47 days, respectively. Updated COVID-19 vaccine provided increased protection against COVID-19-associated ED/UC encounters and hospitalization among immunocompetent adults. These results support CDC recommendations for updated 2023-2024 COVID-19 vaccination. All persons aged ≥6 months should receive updated 2023-2024 COVID-19 vaccine.

PubMed Disclaimer

Conflict of interest statement

All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Steven Y. Chang reports consulting fees from PureTech Health and Kiniksa Pharmaceuticals, and participation on the data safety monitoring board for an unrelated, local study at Ronald Reagan UCLA Medical Center, outside the submitted work. Manjusha Gaglani reports serving as the Texas Pediatric Society, Texas Chapter of the American Academy of Pediatrics co-chair of the ID and Immunization Committee, outside the submitted work. Adit A. Ginde reports support from Biomeme and Seastar, outside the submitted work. Carlos G. Grijalva reports other funding from Merck, contracts from Syneos Health and the Food and Drug Administration, and grants from National Institutes of Health (NIH) and Agency for Health Care Research and Quality, outside the submitted work. Akram Khan reports grant funding from 4DMedical, Dompe Pharmaceuticals, Ely Lilly, and Roche Pharmaceuticals, outside the submitted work. Adam S. Lauring reports research support from the National Institute of Allergy and Infectious Diseases, Michigan Department of Health and Human Services, Burroughs Wellcome Fund, Flu Lab, and consulting fees from Roche, outside the submitted work. Christopher Mallow reports medical legal consulting, outside the submitted work. Emily T. Martin reports research funding from Merck, outside the submitted work. Ithan D. Peltan reports grant support from NIH, Intermountain Research and Medical Foundation, and Janssen Pharmaceuticals, and funding to his institution from Bluejay Diagnostics and Regeneron, outside the submitted work. Karthik Natarajan reports institutional support from NIH, Office of the Director, the National Center for Advancing Translational Sciences, and the National Heart, Lung, and Blood Institute. Brian E. Dixon reports Institutional support from NIH, National Library of Medicine in the form of a T15 training grant in biomedical informatics, salary support from the U.S. Department of Veterans Affairs, royalties from Elsevier, Inc. for a book on health information technology and from Springer Nature for a book on health information technology. Nicola P. Klein reports support from GSK, Merck, Pfizer, Sanofi Pasteur, and Seqirus for work unrelated to this report. No other potential conflicts of interest were disclosed.

References

    1. Regan JJ, Moulia DL, Link-Gelles R, et al. Use of updated COVID-19 vaccines 2023–2024 formula for persons aged ≥6 months: recommendations of the Advisory Committee on Immunization Practices—United States, September 2023. MMWR Morb Mortal Wkly Rep 2023;72:1140–6. 10.15585/mmwr.mm7242e1 - DOI - PMC - PubMed
    1. Link-Gelles R, Weber ZA, Reese SE, et al. Estimates of bivalent mRNA vaccine durability in preventing COVID-19–associated hospitalization and critical illness among adults with and without immunocompromising conditions—VISION network, September 2022–April 2023. MMWR Morb Mortal Wkly Rep 2023;72:579–88. 10.15585/mmwr.mm7221a3 - DOI - PMC - PubMed
    1. DeCuir J, Surie D, Zhu Y, et al. Durability of protection from original monovalent and bivalent COVID-19 vaccines against COVID-19–associated hospitalization and severe in-hospital outcomes among adults in the United States—September 2022–August 2023. medRxiv. [Preprint posted online January 9, 2024]. 10.1101/2024.01.07.24300910v1 - DOI
    1. Doll MK, Pettigrew SM, Ma J, Verma A. Effects of confounding bias in coronavirus disease 2019 (COVID-19) and influenza vaccine effectiveness test-negative designs due to correlated influenza and COVID-19 vaccination behaviors. Clin Infect Dis 2022;75:e564–71. 10.1093/cid/ciac234 - DOI - PMC - PubMed
    1. Yang S, Yu Y, Xu Y, et al. Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure. Lancet Infect Dis 2024;24:e70–2. 10.1016/S1473-3099(23)00744-2 - DOI - PubMed

Substances