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Comment
. 2024 Mar 12;121(11):e2401496121.
doi: 10.1073/pnas.2401496121. Epub 2024 Feb 29.

Telling time in tumor samples reveals diversity of clock disruption

Katja A Lamia  1
Affiliations
Comment

Telling time in tumor samples reveals diversity of clock disruption

Katja A Lamia. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
Sample collection time is rarely recorded when biopsies are performed and is not included in clinical data associated with large sequencing projects. Several informatic approaches have been developed to estimate circadian phase (a proxy for sample collection time) from gene expression data. These methods can be refined by training them on data generated from relatively small sets of time-stamped samples, thus enabling investigation of circadian properties in existing large datasets. This figure was created with Biorender.com.
See this image and copyright information in PMC

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References

    1. Wang C., et al. , Dendritic cells direct circadian anti-tumour immune responses. Nature 614, 136–143 (2023). - PMC - PubMed
    1. Hadadi E., et al. , Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice. Nat. Commun. 11, 3193 (2020). - PMC - PubMed
    1. Aiello I., et al. , Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation. Sci. Adv. 6, eaaz4530 (2020). - PMC - PubMed
    1. Pariollaud M., et al. , Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer. Sci. Adv. 8, eabo1123 (2022). - PMC - PubMed
    1. Chun S. K., et al. , Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer. Sci. Adv. 8, eabo2389 (2022). - PMC - PubMed

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