. 2024 Feb 29;4(2):e0002596.

doi: 10.1371/journal.pgph.0002596. eCollection 2024.

Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys: Time for household-wide interventions?

Yohhei Hamada¹, Matteo Quartagno², Irwin Law³, Farihah Malik⁴, Frank Adae Bonsu⁵, Ifedayo M O Adetifa^{6

7}, Yaw Adusi-Poku⁵, Umberto D'Alessandro⁶, Adedapo Olufemi Bashorun⁶, Vikarunnessa Begum⁸, Dina Bisara Lolong⁹, Tsolmon Boldoo¹⁰, Themba Dlamini¹¹, Simon Donkor⁶, Bintari Dwihardiani¹², Saidi Egwaga¹³, Muhammad N Farid¹⁴, Anna Marie Celina G Garfin¹⁵, Donna Mae G Gaviola¹⁵, Mohammad Mushtuq Husain¹⁶, Farzana Ismail^{17

18}, Mugagga Kaggwa¹⁹, Deus V Kamara¹³, Samuel Kasozi²⁰, Kruger Kaswaswa²¹, Bruce Kirenga²², Eveline Klinkenberg²³, Zuweina Kondo¹³, Adebola Lawanson²⁴, David Macheque²⁵, Ivan Manhiça²⁵, Llang Bridget Maama-Maime²⁶, Sayoki Mfinanga^{1

27

28

29}, Sizulu Moyo^{30

31}, James Mpunga²¹, Thuli Mthiyane³², Dyah Erti Mustikawati³³, Lindiwe Mvusi³⁴, Hoa Binh Nguyen³⁵, Hai Viet Nguyen³⁵, Lamria Pangaribuan³³, Philip Patrobas³⁶, Mahmudur Rahman¹⁶, Mahbubur Rahman¹⁶, Mohammed Sayeedur Rahman⁸, Thato Raleting²⁶, Pandu Riono³⁷, Nunurai Ruswa³⁸, Elizeus Rutebemberwa³⁹, Mugabe Frank Rwabinumi²², Mbazi Senkoro²⁷, Ahmad Raihan Sharif¹⁶, Welile Sikhondze¹¹, Charalambos Sismanidis³, Tugsdelger Sovd⁴⁰, Turyahabwe Stavia²⁰, Sabera Sultana⁸, Oster Suriani³³, Albertina Martha Thomas³⁸, Kristina Tobing⁹, Martie Van der Walt³², Simon Walusimbi²², Mohammad Mostafa Zaman⁸, Katherine Floyd³, Andrew Copas¹, Ibrahim Abubakar¹, Molebogeng X Rangaka^{1

41}

Affiliations

¹ Institute for Global Health, University College London, London, United Kingdom.
² MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom.
³ Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland.
⁴ UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
⁵ National Tuberculosis Programme, Ghana Health Service, Accra, Ghana.
⁶ Disease Control and Elimination Theme, Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, Gambia.
⁷ Department of Infectious Diseases Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
⁸ World Health Organization, Country Office for Bangladesh, Dhaka, Bangladesh.
⁹ National Research and Innovation Agency, Jakarta, Indonesia.
¹⁰ Tuberculosis Surveillance and Research Department, National Center for Communicable Disease, Ulaanbaatar, Mongolia.
¹¹ Eswatini National Tuberculosis Program, Ministry of Health, Mbabane, Eswatini.
¹² Center for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
¹³ Tuberculosis and Leprosy Programme, Ministry of Health and Social Welfare, Dodoma, United Republic of Tanzania.
¹⁴ Expert TB Committee, Jakarta, Indonesia.
¹⁵ National TB Control Program, Department of Health, Manila, Philippines.
¹⁶ Institute of Epidemiology, Disease Control and Research (IEDCR), Dhaka, Bangladesh.
¹⁷ Centre for Tuberculosis: National Institute for Communicable Diseases, a Division of the National Health Laboratory Services, Johannesburg, South Africa.
¹⁸ Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.
¹⁹ World Health Organization, Country Office for Uganda, Kampala, Uganda.
²⁰ National Tuberculosis Control Programme, Ministry of Health, Kampala, Uganda.
²¹ National Tuberculosis Programme, Ministry of Health, Lilongwe, Malawi.
²² Makerere University Lung Institute, Kampala, Uganda.
²³ Department of Global Health, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
²⁴ National Tuberculosis and Leprosy Control Programme, Federal Ministry of Health, Abuja, Nigeria.
²⁵ National Tuberculosis Program, Ministry of Health, Maputo, Mozambique.
²⁶ National TB and Leprosy Programme, Ministry of Health, Maseru, Lesotho.
²⁷ National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, United Republic of Tanzania.
²⁸ Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
²⁹ Department of Epidemiology, Alliance for Africa Health and Research, Dar es Salaam, United Republic of Tanzania.
³⁰ Human and Social Capabilities Division, Human Sciences Research Council, Pretoria, South Africa.
³¹ School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
³² South African Medical Research Council, Cape Town, South Africa.
³³ Ministry of Health, Jakarta, Indonesia.
³⁴ National Department of Health, Pretoria, South Africa.
³⁵ National Tuberculosis Programme, Hanoi, Viet Nam.
³⁶ World Health Organization, Country Office for Nigeria, Abuja, Nigeria.
³⁷ Department of Biostatistics and Population, Faculty of Public Health, University of Indonesia, Depok, Indonesia.
³⁸ National TB and Leprosy Programme, Ministry of Health and Social Services, Windhoek, Namibia.
³⁹ Department of Health Policy, Planning and Management, Makerere University School of Public Health, Kampala, Uganda.
⁴⁰ Department of Monitoring and Evaluation and Internal Audit, Ministry of Health, Ulaanbaatar, Mongolia.
⁴¹ Division of Epidemiology and Biostatistics & CIDRI-AFRICA, University of Cape Town, Cape Town, South Africa.

PMID: 38422092
PMCID: PMC10903843
DOI: 10.1371/journal.pgph.0002596

Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys: Time for household-wide interventions?

Yohhei Hamada et al. PLOS Glob Public Health. 2024.

. 2024 Feb 29;4(2):e0002596.

doi: 10.1371/journal.pgph.0002596. eCollection 2024.

Authors

Affiliations

¹ Institute for Global Health, University College London, London, United Kingdom.
² MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, United Kingdom.
³ Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland.
⁴ UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
⁵ National Tuberculosis Programme, Ghana Health Service, Accra, Ghana.
⁶ Disease Control and Elimination Theme, Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, Gambia.
⁷ Department of Infectious Diseases Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
⁸ World Health Organization, Country Office for Bangladesh, Dhaka, Bangladesh.
⁹ National Research and Innovation Agency, Jakarta, Indonesia.
¹⁰ Tuberculosis Surveillance and Research Department, National Center for Communicable Disease, Ulaanbaatar, Mongolia.
¹¹ Eswatini National Tuberculosis Program, Ministry of Health, Mbabane, Eswatini.
¹² Center for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
¹³ Tuberculosis and Leprosy Programme, Ministry of Health and Social Welfare, Dodoma, United Republic of Tanzania.
¹⁴ Expert TB Committee, Jakarta, Indonesia.
¹⁵ National TB Control Program, Department of Health, Manila, Philippines.
¹⁶ Institute of Epidemiology, Disease Control and Research (IEDCR), Dhaka, Bangladesh.
¹⁷ Centre for Tuberculosis: National Institute for Communicable Diseases, a Division of the National Health Laboratory Services, Johannesburg, South Africa.
¹⁸ Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.
¹⁹ World Health Organization, Country Office for Uganda, Kampala, Uganda.
²⁰ National Tuberculosis Control Programme, Ministry of Health, Kampala, Uganda.
²¹ National Tuberculosis Programme, Ministry of Health, Lilongwe, Malawi.
²² Makerere University Lung Institute, Kampala, Uganda.
²³ Department of Global Health, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
²⁴ National Tuberculosis and Leprosy Control Programme, Federal Ministry of Health, Abuja, Nigeria.
²⁵ National Tuberculosis Program, Ministry of Health, Maputo, Mozambique.
²⁶ National TB and Leprosy Programme, Ministry of Health, Maseru, Lesotho.
²⁷ National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, United Republic of Tanzania.
²⁸ Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
²⁹ Department of Epidemiology, Alliance for Africa Health and Research, Dar es Salaam, United Republic of Tanzania.
³⁰ Human and Social Capabilities Division, Human Sciences Research Council, Pretoria, South Africa.
³¹ School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
³² South African Medical Research Council, Cape Town, South Africa.
³³ Ministry of Health, Jakarta, Indonesia.
³⁴ National Department of Health, Pretoria, South Africa.
³⁵ National Tuberculosis Programme, Hanoi, Viet Nam.
³⁶ World Health Organization, Country Office for Nigeria, Abuja, Nigeria.
³⁷ Department of Biostatistics and Population, Faculty of Public Health, University of Indonesia, Depok, Indonesia.
³⁸ National TB and Leprosy Programme, Ministry of Health and Social Services, Windhoek, Namibia.
³⁹ Department of Health Policy, Planning and Management, Makerere University School of Public Health, Kampala, Uganda.
⁴⁰ Department of Monitoring and Evaluation and Internal Audit, Ministry of Health, Ulaanbaatar, Mongolia.
⁴¹ Division of Epidemiology and Biostatistics & CIDRI-AFRICA, University of Cape Town, Cape Town, South Africa.

PMID: 38422092
PMCID: PMC10903843
DOI: 10.1371/journal.pgph.0002596

Abstract

Tuberculosis (TB) and non-communicable diseases (NCD) share predisposing risk factors. TB-associated NCD might cluster within households affected with TB requiring shared prevention and care strategies. We conducted an individual participant data meta-analysis of national TB prevalence surveys to determine whether NCD cluster in members of households with TB. We identified eligible surveys that reported at least one NCD or NCD risk factor through the archive maintained by the World Health Organization and searching in Medline and Embase from 1 January 2000 to 10 August 2021, which was updated on 23 March 2023. We compared the prevalence of NCD and their risk factors between people who do not have TB living in households with at least one person with TB (members of households with TB), and members of households without TB. We included 16 surveys (n = 740,815) from Asia and Africa. In a multivariable model adjusted for age and gender, the odds of smoking was higher among members of households with TB (adjusted odds ratio (aOR) 1.23; 95% CI: 1.11-1.38), compared with members of households without TB. The analysis did not find a significant difference in the prevalence of alcohol drinking, diabetes, hypertension, or BMI between members of households with and without TB. Studies evaluating household-wide interventions for smoking to reduce its dual impact on TB and NCD may be warranted. Systematically screening for NCD using objective diagnostic methods is needed to understand the actual burden of NCD and inform comprehensive interventions.

Copyright: © 2024 Hamada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Conflict of interest statement

TSo declares a receipt of funding from the Global Fund for conducting the TB prevalence survey in Mongolia. All other authors declare no competing interests.

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References

1. Marais BJ, Lönnroth K, Lawn SD, Migliori GB, Mwaba P, Glaziou P, et al.. Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services and control efforts. The Lancet Infectious Diseases. 2013;13(5):436–48. doi: 10.1016/S1473-3099(13)70015-X - DOI - PubMed
1. Global Burden of Disease Collaborative Network. Global Burden of Disease Study 2019 (GBD 2019) Results. Seattle, United States: Institute for Health Metrics and Evaluation (IHME), 2020. Available from: http://ghdx.healthdata.org/gbd-results-tool.
1. World Health Organization. Global TB Report, 2022. Geneva, Switzerland: WHO, 2022. Available from: https://apps.who.int/iris/rest/bitstreams/1474924/retrieve.
1. Baghaei P, Marjani M, Javanmard P, Tabarsi P, Masjedi MR. Diabetes mellitus and tuberculosis facts and controversies. J Diabetes Metab Disord. 2013;12(1):58. Epub 20131220. doi: 10.1186/2251-6581-12-58 ; PubMed Central PMCID: PMC7962555. - DOI - PMC - PubMed
1. Romanowski K, Clark EG, Levin A, Cook VJ, Johnston JC. Tuberculosis and chronic kidney disease: an emerging global syndemic. Kidney Int. 2016;90(1):34–40. doi: 10.1016/j.kint.2016.01.034 - DOI - PubMed

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Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys: Time for household-wide interventions?

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Tobacco smoking clusters in households affected by tuberculosis in an individual participant data meta-analysis of national tuberculosis prevalence surveys: Time for household-wide interventions?

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Abstract

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