doi: 10.1016/0027-5107(79)90127-1.
Mitochondrial mutagenesis in Saccharomyces cerevisiae. II. Methyl methanesulphonate and diepoxybutane
- PMID: 384223
- DOI: 10.1016/0027-5107(79)90127-1
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Mitochondrial mutagenesis in Saccharomyces cerevisiae. II. Methyl methanesulphonate and diepoxybutane
Mutat Res.
1979 Jul.
Abstract
In Saccharomyces cerevisiae, methyl methanesulphonate and diepoxybutane produced efficiently lethal, as well as mutagenic, damage in nuclear DNA. However, in the same conditions, these agents did not induce cytoplasmic petite mutations and poorly induced point mutations (resistance to erythromycin and chloramphenicol) in mitochondrial DNA. Possible reasons for these differences are discussed.
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