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Review
. 2024 Apr;71(2):241-252.
doi: 10.1016/j.pcl.2024.01.004. Epub 2024 Feb 2.

Autism and Epilepsy

Jamie K Capal  1 , Shafali S Jeste  2
Affiliations
Review

Autism and Epilepsy

Jamie K Capal et al. Pediatr Clin North Am. 2024 Apr.

Abstract

Epilepsy is one of the most common comorbidities in individuals with autism spectrum disorders (ASDs). Risk factors include the presence of developmental delay/intellectual disability, female sex, age, and an underlying genetic condition. Due to higher prevalence of epilepsy in ASD, it is important to have a high index of suspicion for seizures and refer to a neurologist if there are concerns. Genetic testing is recommended for all children with ASD but it becomes more high yield in children with epilepsy and ASD.

Keywords: Autism spectrum disorder; Epilepsy; Genetics.

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Conflict of interest statement

Disclosure J.K. Capal has no financial or commercial conflicts of interest. She receives funding from the Department of Defense, United States and National Institute of Health (NIH), United States for unrelated projects. She receives grant funding from NIH and the Simons Foundation, United States. S.S. Jeste serves on the data safety monitoring board for Ionis Pharmaceuticals. She previously consulted for Roche pharmaceuticals. She receives funding from the NIH, Roche pharmaceuticals, the Saban Research Institute, United States, the Autism Science Foundation, United States, and the Simons Foundation for unrelated projects.

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