Digital computerised cognitive training for preventing cognitive decline among hypertensive patients: a study protocol for a multicentre randomised controlled trial (DELIGHT trial)

doi:10.1136/bmjopen-2023-079305

. 2024 Feb 29;14(2):e079305.

doi: 10.1136/bmjopen-2023-079305.

Digital computerised cognitive training for preventing cognitive decline among hypertensive patients: a study protocol for a multicentre randomised controlled trial (DELIGHT trial)

Yu Kong^{1

2}, Qian Hui Guo³, Le Zhou¹, Liu He^{1

2}, Yong Zeng¹, Xin Du^{1

2

4}, Jian Zeng Dong¹, Chao Jiang^#⁵, Ji Guang Wang^#⁶, Chang Sheng Ma¹

Affiliations

¹ Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases Prevention, Chaoyang Qu, Beijing, China.
² Heart Health Research Center, Beijing, China.
³ Department of Cardiovascular Medicine, State Key Laboratory of Medical Geonomics, Shanghai Key Laboratory of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
⁴ University of New South Wales, Sydney, New South Wales, Australia.
⁵ Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases Prevention, Chaoyang Qu, Beijing, China superj@zju.edu.cn jiguangwang@aim.com.
⁶ Department of Cardiovascular Medicine, State Key Laboratory of Medical Geonomics, Shanghai Key Laboratory of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China superj@zju.edu.cn jiguangwang@aim.com.

^# Contributed equally.

PMID: 38423771
PMCID: PMC10910859
DOI: 10.1136/bmjopen-2023-079305

Digital computerised cognitive training for preventing cognitive decline among hypertensive patients: a study protocol for a multicentre randomised controlled trial (DELIGHT trial)

Yu Kong et al. BMJ Open. 2024.

. 2024 Feb 29;14(2):e079305.

doi: 10.1136/bmjopen-2023-079305.

Authors

Yu Kong^{1

2}, Qian Hui Guo³, Le Zhou¹, Liu He^{1

2}, Yong Zeng¹, Xin Du^{1

2

4}, Jian Zeng Dong¹, Chao Jiang^#⁵, Ji Guang Wang^#⁶, Chang Sheng Ma¹

Affiliations

¹ Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases Prevention, Chaoyang Qu, Beijing, China.
² Heart Health Research Center, Beijing, China.
³ Department of Cardiovascular Medicine, State Key Laboratory of Medical Geonomics, Shanghai Key Laboratory of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
⁴ University of New South Wales, Sydney, New South Wales, Australia.
⁵ Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases Prevention, Chaoyang Qu, Beijing, China superj@zju.edu.cn jiguangwang@aim.com.
⁶ Department of Cardiovascular Medicine, State Key Laboratory of Medical Geonomics, Shanghai Key Laboratory of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China superj@zju.edu.cn jiguangwang@aim.com.

^# Contributed equally.

PMID: 38423771
PMCID: PMC10910859
DOI: 10.1136/bmjopen-2023-079305

Abstract

Introduction: Mild cognitive impairment (MCI) is an important intervenable stage for the prevention of dementia. Hypertension is associated with impaired cognition, and when combined with MCI, it may lead to a poor prognosis. Digital computerised cognitive training (CCT) has recently become a potential instrument for improving cognition, but evidence for its efficacy remains limited. This study aims to evaluate the efficacy of a digital adaptive CCT intervention in older patients with hypertension and MCI.

Methods and analysis: The multicentre, double-blinded, randomised, actively -controlled clinical trial will recruit 200 older (≥60 years) patients with hypertension and MCI from 11 hospitals across China. Participants will be randomly assigned in a 1:1 ratio to the intervention group (multidomain adaptative CCT) and active control group (non-adaptive cognitive training) for 12-week cognitive training for 30 min/day and 5 days/week. Those who have completed their 12-week training in the intervention group will be rerandomised into the continuation and discontinuation training groups. All participants will be followed up to 24 weeks. Neuropsychological assessments and structural and functional 7.0 T MRI will be obtained at baseline and at 12-week and 24-week follow-up. The primary outcome is the possible improvement of global cognitive function at 12 weeks, as measured by the Basic Cognitive Aptitude Tests. Secondary and exploratory endpoints include the major cognitive domain function improvement, self-efficacy, mental health, quality of life and MRI measurements of the brain.

Ethics and dissemination: The trial has been approved by the institutional review board of Beijing Anzhen Hospital and thereafter by all other participating centres. Trial findings will be disseminated in peer-reviewed journals and conference presentations.

Trial registration number: NCT05704270.

Keywords: CARDIOLOGY; Delirium & cognitive disorders; Hypertension; Nephrology.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

**Figure 1**
Flow chart. MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment Scale.

See this image and copyright information in PMC

References

1. Lobanov-Rostovsky S, He Q, Chen Y, et al. . Growing old in China in socioeconomic and Epidemiological context: systematic review of social care policy for older people. BMC Public Health 2023;23. 10.1186/s12889-023-15583-1 - DOI - PMC - PubMed
1. Liu Y, Ma W, Li M, et al. . Relationship between physical performance and mild cognitive impairment in Chinese community-dwelling older adults. Clin Interv Aging 2021;16:119–27. 10.2147/CIA.S288164 - DOI - PMC - PubMed
1. Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol 2020;16:223–37. 10.1038/s41581-019-0244-2 - DOI - PMC - PubMed
1. Ungvari Z, Toth P, Tarantini S, et al. . Hypertension-induced cognitive impairment: from pathophysiology to public health. Nat Rev Nephrol 2021;17:639–54. 10.1038/s41581-021-00430-6 - DOI - PMC - PubMed
1. Peters R, Schuchman M, Peters J, et al. . Relationship between antihypertensive medications and cognitive impairment: part II. Curr Hypertens Rep 2016;18. 10.1007/s11906-016-0673-2 - DOI - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Associated data

Actions
- Search in PubMed
- Search in ClinicalTrials.gov

LinkOut - more resources

Full Text Sources
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information

[1] Lobanov-Rostovsky S, He Q, Chen Y, et al. . Growing old in China in socioeconomic and Epidemiological context: systematic review of social care policy for older people. BMC Public Health 2023;23. 10.1186/s12889-023-15583-1 - DOI - PMC - PubMed

[2] Lobanov-Rostovsky S, He Q, Chen Y, et al. . Growing old in China in socioeconomic and Epidemiological context: systematic review of social care policy for older people. BMC Public Health 2023;23. 10.1186/s12889-023-15583-1 - DOI - PMC - PubMed

[3] Liu Y, Ma W, Li M, et al. . Relationship between physical performance and mild cognitive impairment in Chinese community-dwelling older adults. Clin Interv Aging 2021;16:119–27. 10.2147/CIA.S288164 - DOI - PMC - PubMed

[4] Liu Y, Ma W, Li M, et al. . Relationship between physical performance and mild cognitive impairment in Chinese community-dwelling older adults. Clin Interv Aging 2021;16:119–27. 10.2147/CIA.S288164 - DOI - PMC - PubMed

[5] Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol 2020;16:223–37. 10.1038/s41581-019-0244-2 - DOI - PMC - PubMed

[6] Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol 2020;16:223–37. 10.1038/s41581-019-0244-2 - DOI - PMC - PubMed

[7] Ungvari Z, Toth P, Tarantini S, et al. . Hypertension-induced cognitive impairment: from pathophysiology to public health. Nat Rev Nephrol 2021;17:639–54. 10.1038/s41581-021-00430-6 - DOI - PMC - PubMed

[8] Ungvari Z, Toth P, Tarantini S, et al. . Hypertension-induced cognitive impairment: from pathophysiology to public health. Nat Rev Nephrol 2021;17:639–54. 10.1038/s41581-021-00430-6 - DOI - PMC - PubMed

[9] Peters R, Schuchman M, Peters J, et al. . Relationship between antihypertensive medications and cognitive impairment: part II. Curr Hypertens Rep 2016;18. 10.1007/s11906-016-0673-2 - DOI - PMC - PubMed

[10] Peters R, Schuchman M, Peters J, et al. . Relationship between antihypertensive medications and cognitive impairment: part II. Curr Hypertens Rep 2016;18. 10.1007/s11906-016-0673-2 - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Digital computerised cognitive training for preventing cognitive decline among hypertensive patients: a study protocol for a multicentre randomised controlled trial (DELIGHT trial)

Affiliations

Digital computerised cognitive training for preventing cognitive decline among hypertensive patients: a study protocol for a multicentre randomised controlled trial (DELIGHT trial)

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

References

Publication types

MeSH terms

Associated data

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Figures

Similar articles

References

Publication types

MeSH terms

Associated data

Related information

LinkOut - more resources

Full Text Sources

Medical