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Comment
. 2024 Mar 1;5(1):8.
doi: 10.1186/s43556-023-00169-5.

Structural and functional insights of NINJ1 in plasma membrane rupture during cell death

Chehao Lee  1 , Yuqing Liang  2 , Yang Li  3
Affiliations
Comment

Structural and functional insights of NINJ1 in plasma membrane rupture during cell death

Chehao Lee et al. Mol Biomed. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Fig. 1
Fig. 1
The model of PMR induced by NINJ1. a. Structural representation of NINJ1. b. Mechanism diagram illustrating NINJ1 oligomerization. c. NINJ1 oligomerization triggers PMR
See this image and copyright information in PMC

Comment on

  • Structural basis of NINJ1-mediated plasma membrane rupture in cell death.
    Degen M, Santos JC, Pluhackova K, Cebrero G, Ramos S, Jankevicius G, Hartenian E, Guillerm U, Mari SA, Kohl B, Müller DJ, Schanda P, Maier T, Perez C, Sieben C, Broz P, Hiller S. Degen M, et al. Nature. 2023 Jun;618(7967):1065-1071. doi: 10.1038/s41586-023-05991-z. Epub 2023 May 17. Nature. 2023. PMID: 37198476 Free PMC article.

References

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    1. Lee H-J, Ahn BJ, Shin MW, Choi J-H, Kim K-W. Ninjurin1: a potential adhesion molecule and its role in inflammation and tissue remodeling. Mol Cells. 2010;29(3):223–227. doi: 10.1007/s10059-010-0043-x. - DOI - PubMed
    1. Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O’Rourke K, Li Q, et al. NINJ1 mediates plasma membrane rupture during lytic cell death. Nature. 2021;591(7848):131–136. doi: 10.1038/s41586-021-03218-7. - DOI - PubMed
    1. Kayagaki N, Stowe IB, Alegre K, Deshpande I, Wu S, Lin Z, et al. Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury. Nature. 2023;618(7967):1072–1077. doi: 10.1038/s41586-023-06191-5. - DOI - PMC - PubMed
    1. Lee C, Xin G, Li F, Wan C, Yu X, Feng L, et al. Calcium/P53/Ninjurin 1 signaling mediates plasma membrane rupture of Acinar cells in severe Acute Pancreatitis. Int J Mol Sci. 2023;24(14):11554. doi: 10.3390/ijms241411554. - DOI - PMC - PubMed

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