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Case Reports
. 2024 Mar 1;18(1):81.
doi: 10.1186/s13256-024-04387-5.

Human herpesvirus-6 infection in a critically ill and immunocompetent patient: a case report

Xin Tian Chia  1 , Hai Liang Marc Wong  2 , Jia Shen Loh  2   3
Affiliations
Case Reports

Human herpesvirus-6 infection in a critically ill and immunocompetent patient: a case report

Xin Tian Chia et al. J Med Case Rep. .

Abstract

Background: Human herpesvirus-6 is a rare infection in an immunocompetent adult. In existing literature, there is a dearth of knowledge that mainly exists as case reports and case series.

Case presentation: In this case report, we described a 29-year-old female of Myanmarese descent patient from Myanmar who presented with altered mental status and non-specific respiratory and gastrointestinal symptoms. She was initially treated for pneumonia and discharged well. However, she re-presented to the hospital and was subsequently treated for severe central nervous system infection. Cerebrospinal fluid studies detected human herpesvirus-6 polymerase chain reaction with associated high serum human herpesvirus-6 concentration. This infection also triggered hemophagocytic lymphohistiocytosis. Treatment was initiated against both human herpesvirus-6 infection and hemophagocytic lymphohistiocytosis, and she responded to antiviral treatment and steroids, respectively.

Conclusion: This case study highlights the need for prompt diagnosis and treatment of this severe disease and the dangerous complications. Additionally, the authors share insights on the diagnostic challenges faced in the treatment of this patient.

Keywords: Chromosomally integrated HHV-6; Human herpesvirus-6; Immunocompetent.

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Conflict of interest statement

No competing interests.

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References

    1. Campadelli-Fiume G, Mirandola P, Menotti L. Human Herpesvirus 6: an emerging pathogen. Emerg Infect Dis J. 1999;5(3):353. doi: 10.3201/eid0503.990306. - DOI - PMC - PubMed
    1. Luppi M, Barozzi P, Maiorana A, Marasca R, Torelli G. Human Herpesvirus 6 infection in normal human brain tissue. J Infect Dis. 1994;169(4):943–944. doi: 10.1093/infdis/169.4.943. - DOI - PubMed
    1. Knox KK, Carrigan DR. Active HHV-6 infection in the lymph nodes of HIV-infected patients: in vitro evidence that HHV-6 can break HIV latency. JAIDS J Acquired Immune Deficiency Syndr. 1996;11(4):370–378. doi: 10.1097/00042560-199604010-00007. - DOI - PubMed
    1. Singh N, Paterson DL. Encephalitis caused by human herpesvirus-6 in transplant recipients: relevance of a novel neurotropic virus. Transplantation. 2000;69(12):2474–2479. doi: 10.1097/00007890-200006270-00002. - DOI - PubMed
    1. Trabue CH, Bloch KC, Myers JW, Moorman JP. Case report and literature review: HHV-6-associated meningoencephalitis in an immunocompetent adult. Herpes J IHMF. 2008;15(2):33–35. - PubMed

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