Gastrointestinal Bleeding in Patients With Acute Ischemic Stroke: A Literature Review
- PMID: 38425599
- PMCID: PMC10902729
- DOI: 10.7759/cureus.53210
Gastrointestinal Bleeding in Patients With Acute Ischemic Stroke: A Literature Review
Abstract
Stroke is an infarction of the central nervous system (brain, spinal cord, or retina) that results from a disruption in cerebral blood flow either due to ischemia or hemorrhage. Complications of acute stroke are common and include pneumonia, urinary tract infection, myocardial infarction, deep vein thrombosis, and pulmonary embolism, among several others, all of which increase the risk of poor clinical outcomes. Gastrointestinal bleeding is a well-known complication that can occur during the acute phase of stroke. In this review, we have summarized the existing data regarding the incidence, pathophysiology, risk factors, morbidity, mortality, and management strategies for gastrointestinal bleeding in patients with acute ischemic stroke.
Keywords: anticoagulants; cerebrovascular accident; gastrointestinal bleeding; gastrointestinal hemorrhage; ischemic stroke.
Copyright © 2024, Aziz et al.
Conflict of interest statement
The authors have declared that no competing interests exist.
Similar articles
-
A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT.Health Technol Assess. 2021 Oct;25(58):1-86. doi: 10.3310/hta25580. Health Technol Assess. 2021. PMID: 34663491 Clinical Trial.
-
Anticoagulant Use and Risk of Ischemic Stroke and Bleeding in Patients With Secondary Atrial Fibrillation Associated With Acute Coronary Syndromes, Acute Pulmonary Disease, or Sepsis.JACC Clin Electrophysiol. 2018 Mar;4(3):386-393. doi: 10.1016/j.jacep.2017.08.003. Epub 2017 Sep 27. JACC Clin Electrophysiol. 2018. PMID: 30089566
-
Medical complications among hospitalizations for ischemic stroke in the United States from 1998 to 2007.Stroke. 2010 May;41(5):980-6. doi: 10.1161/STROKEAHA.110.578674. Epub 2010 Mar 4. Stroke. 2010. PMID: 20203317
-
Dual therapy with oral anticoagulation and single antiplatelet agent versus monotherapy with oral anticoagulation alone in patients with atrial fibrillation and stable ischemic heart disease: a systematic review and meta-analysis.J Interv Card Electrophysiol. 2023 Mar;66(2):493-506. doi: 10.1007/s10840-022-01347-1. Epub 2022 Sep 9. J Interv Card Electrophysiol. 2023. PMID: 36085242
-
Nonvitamin-K-antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and previous stroke or transient ischemic attack: An updated systematic review and meta-analysis of randomized controlled trials.Int J Stroke. 2017 Aug;12(6):589-596. doi: 10.1177/1747493017700663. Epub 2017 Mar 15. Int J Stroke. 2017. PMID: 28730948
Cited by
-
Risk factors and predictive model for gastrointestinal bleeding in patients with ischemic stroke: a case-control study.Am J Transl Res. 2025 Jul 15;17(7):5011-5024. doi: 10.62347/EOOS8728. eCollection 2025. Am J Transl Res. 2025. PMID: 40821074 Free PMC article.
-
Does a History of Stroke Affect Outcomes in Non-variceal Upper Gastrointestinal Bleeding?Cureus. 2025 Jul 31;17(7):e89159. doi: 10.7759/cureus.89159. eCollection 2025 Jul. Cureus. 2025. PMID: 40755614 Free PMC article.
References
-
- Centers for Disease Control and Prevention. Stroke. Stroke. [ Jan; 2024 ]. 2023. https://www.cdc.gov/stroke/ https://www.cdc.gov/stroke/
-
- Gastrointestinal complications after ischemic stroke. Camara-Lemarroy CR, Ibarra-Yruegas BE, Gongora-Rivera F. J Neurol Sci. 2014;346:20–25. - PubMed
-
- Gastrointestinal hemorrhage after acute stroke. Davenport RJ, Dennis MS, Warlow CP. Stroke. 1996;27:421–424. - PubMed
-
- Gastrointestinal hemorrhage after acute ischemic stroke and its risk factors in Asians. Hsu HL, Lin YH, Huang YC, Weng HH, Lee M, Huang WY, Lee JD. Eur Neurol. 2009;62:212–218. - PubMed
Publication types
LinkOut - more resources
Full Text Sources