Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Feb 28;11(3):e01281.
doi: 10.14309/crj.0000000000001281. eCollection 2024 Mar.

Autologous Gastrointestinal Graft-vs-Host Disease in a Patient With Multiple Myeloma and Hematopoietic Stem Cell Transplantation

Hasan Raza  1 , Sandra Naffouj  2 , Grace Guzman  3 , Asim Shuja  2
Affiliations
Case Reports

Autologous Gastrointestinal Graft-vs-Host Disease in a Patient With Multiple Myeloma and Hematopoietic Stem Cell Transplantation

Hasan Raza et al. ACG Case Rep J. .

Abstract

Graft-vs-host disease (GVHD) of the gastrointestinal (GI) tract is notably a serious complication of allogeneic hematopoietic stem cell transplant (HSCT). However, GI GVHD has rarely been reported in autologous HSCT, and the pathophysiology remains unclear. Diagnosing GVHD after autologous HSCT requires a high level of clinical suspicion, given its nonspecific clinical presentation and endoscopic findings necessitating a histological diagnosis for confirmation. We present a case of autologous GVHD involving the GI tract in a patient with multiple myeloma who responded well to corticosteroids, highlighting the importance of early identification of this rare entity to initiate therapy and improve outcomes.

Keywords: autologous; colitis; gastrointestinal tract; graft-vs-host disease; stem cell transplant.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Colonoscopy findings of the descending and sigmoid colon showing granularity, erythema, congestion, and decreased vascular pattern in (A) and (B). High power magnification reveals colonic mucosa with prominent microscopic bleb formation and associated apoptotic bodies in both the ascending and descending colonic mucosal biopsies (black circles) noted in (C), (D), and (E).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Goddard DS, Ruben BS, Mathes ED, Nixon M, Wolf J, Fox LP. A case of severe cutaneous, GI and liver GVHD in a patient with multiple myeloma, status-post-second auto-SCT. Bone Marrow Transpl. 2010;45(2):409–11. - PubMed
    1. Hammami MB, Talkin R, Al-Taee AM, Schoen MW, Goyal SD, Lai JP. Autologous graft-versus-host disease of the gastrointestinal tract in patients with multiple myeloma and hematopoietic stem cell transplantation. Gastroenterol Res. 2018;11(1):52–7. - PMC - PubMed
    1. Lazarus HM, Sommers SR, Arfons LM, et al. Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: Flow cytometric analysis of hematopoietic progenitor cell grafts. Biol Blood Marrow Transpl. 2011;17(7):970–8. - PubMed
    1. Drobyski WR, Hari P, Keever-Taylor C, Komorowski R, Grossman W.Severe autologous GVHD after hematopoietic progenitor cell transplantation for multiple myeloma. Bone Marrow Transpl. 2009;43(2):169–77. - PubMed
    1. Cogbill CH, Drobyski WR, Komorowski RA. Gastrointestinal pathology of autologous graft-versus-host disease following hematopoietic stem cell transplantation: A clinicopathological study of 17 cases. Mod Pathol. 2011;24(1):117–25. - PubMed

Publication types