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Case Reports
. 2024 Feb 28;11(3):e01281.
doi: 10.14309/crj.0000000000001281. eCollection 2024 Mar.

Autologous Gastrointestinal Graft-vs-Host Disease in a Patient With Multiple Myeloma and Hematopoietic Stem Cell Transplantation

Hasan Raza  1 , Sandra Naffouj  2 , Grace Guzman  3 , Asim Shuja  2
Affiliations
Case Reports

Autologous Gastrointestinal Graft-vs-Host Disease in a Patient With Multiple Myeloma and Hematopoietic Stem Cell Transplantation

Hasan Raza et al. ACG Case Rep J. .

Abstract

Graft-vs-host disease (GVHD) of the gastrointestinal (GI) tract is notably a serious complication of allogeneic hematopoietic stem cell transplant (HSCT). However, GI GVHD has rarely been reported in autologous HSCT, and the pathophysiology remains unclear. Diagnosing GVHD after autologous HSCT requires a high level of clinical suspicion, given its nonspecific clinical presentation and endoscopic findings necessitating a histological diagnosis for confirmation. We present a case of autologous GVHD involving the GI tract in a patient with multiple myeloma who responded well to corticosteroids, highlighting the importance of early identification of this rare entity to initiate therapy and improve outcomes.

Keywords: autologous; colitis; gastrointestinal tract; graft-vs-host disease; stem cell transplant.

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Figures

Figure 1.
Figure 1.
Colonoscopy findings of the descending and sigmoid colon showing granularity, erythema, congestion, and decreased vascular pattern in (A) and (B). High power magnification reveals colonic mucosa with prominent microscopic bleb formation and associated apoptotic bodies in both the ascending and descending colonic mucosal biopsies (black circles) noted in (C), (D), and (E).
See this image and copyright information in PMC

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