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. 2024 Mar 1;24(1):48.
doi: 10.1007/s10238-024-01306-2.

Lymphoma relapse 1 year or later after immunochemotherapy in DLBCL patients: clinical features and outcome

Hongyun Chen  1 , Jinrong Zhao  1 , Danqing Zhao  1 , Wei Wang  1 , Chong Wei  1 , Zi Wang  1 , Daobin Zhou  2 , Wei Zhang  3
Affiliations

Lymphoma relapse 1 year or later after immunochemotherapy in DLBCL patients: clinical features and outcome

Hongyun Chen et al. Clin Exp Med. .

Abstract

Despite great advances in treatment, 30-40% of patients with DLBCL undergo relapses. Patients with a relapse within 1 year or beyond have a distinct outcome. Few clinical characteristics and survival data in the Chinese population have been published. We aimed to define the incidence and clinical features of DLBCL patients with very early relapse after front-line immunochemotherapy who may benefit greatly from the emerging chimeric antigen receptor T-cell therapy. Data of 564 DLBCL patients were analyzed. Among the 413 patients achieving a first complete remission, 59 underwent relapses: 32 patients (54.2%) relapsed within 1 year, and 27 patients (46.8%) relapsed 1 year or more. Patients relapsing within 1 year, in comparison with the other group, showed an inferior risk profile at diagnosis: elevated lactate dehydrogenase level (P = 0.002), high Eastern Cooperative Oncology Group performance score (P = 0.02), and high international prognosis index (P = 0.004). As expected, a worse overall survival was observed in the early relapse group. Multivariate analysis for OS showed that relapse within 1 year was an independent parameter for reduced overall survival (HR 0.241, P = 0.002).

Keywords: Diffuse large B-cell lymphoma; Relapse; Risk factors; Survival.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of patients relapsing after a first complete remission
Fig. 2
Fig. 2
Kaplan–Meier estimates of overall survival from the first relapse following a complete remission after front-line treatment in patients with DLBCL
See this image and copyright information in PMC

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