[Investigation of a French cohort of neonatal anoxo-ischemic encephalopathy in the era of therapeutic hypothermia: Questions and answers]

Abstract

Objective: To improve knowledge of neonatal hypoxic-ischemic encephalopathy, a prospective, nationwide, population-based cohort of affected children is being set up between September 2015 and March 2017.

Methods: During this period, 794 cases are collected, with information on pregnancy, delivery, neonatal stay and outcome at the end of hospitalization. Clinical and parental questionnaire follow-up is planned until the child is 4 years old.

Results: This article presents the clinical presentation of the newborns included, the analysis of factors associated with short-term outcome at hospital discharge and the organizational factors associated with treatment with therapeutic hypothermia.

Conclusion: These data illustrate the value of a prospective cohort to analyze the management of anoxo-ischemic encephalopathy in France.

Keywords: Devenir à court terme; Encéphalopathie néonatale; Facteur de risque; Hypothermie thérapeutique; Neonatal encephalopathy; Optimal care; Risk factors; Short-term outcome; Soins optimaux; Therapeutic hypothermia.