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Meta-Analysis
. 2024 Mar 1;103(9):e37361.
doi: 10.1097/MD.0000000000037361.

Association between vitamin D receptor gene polymorphisms and genetic susceptibility to benign prostatic hyperplasia: A systematic review and meta-analysis

Li Ruan  1
Affiliations
Meta-Analysis

Association between vitamin D receptor gene polymorphisms and genetic susceptibility to benign prostatic hyperplasia: A systematic review and meta-analysis

Li Ruan. Medicine (Baltimore). .

Abstract

Background: Benign prostatic hyperplasia (BPH) is one of the global public health challenges due to the complexity of its mechanisms of occurrence. Many studies have suggested that vitamin D receptor gene polymorphisms are associated with BPH susceptibility. Still, their conflicting findings need to be analyzed in aggregate to gain a better understanding.

Methods: We identified 10 trials involving 1539 BPH cases and 1915 controls through a systematic search of Embase using, data obtained from the Web of Science, PubMed, and China Knowledge Network databases as of December 31, 2021. A meta-analysis was performed to investigate the association between 4 constant polymorphisms of this associated vitamin D receptor gene (Fok-1, Bsm-1, Taq-1, and Apa-1) and BPH risk.

Results: In the overall population analysis, a significant positive association with BPH risk was found only in the Taq-1 variant (P < .001). Of these, the pure-hybrid model (95% confidence interval [CI] = 1.384-3.196), the heterozygous model (95% CI = 1.207-2.021), the dominant model (95% CI = 1.312-2.133) and the allelic inheritance model (95% CI = 1.205-1.730) showed low heterogeneity. In subtype analyses, Bsm-1 variants showed a significant association with BPH risk for both the recessive (95% CI = 0.100-0.943, P = .039) and over-dominant (95% CI = 1.553-3.100, P = 0) models in the Caucasian population, and for the recessive (95% CI = 1.242-3.283, P = .039) and over-dominant (95% CI = 0.281-0.680, P = 0) models in the Asian population. In addition, a high degree of heterogeneity was found in the subgroup analysis of the association between Fok-1 variants and BPH risk.

Conclusion: Overall, there is an association between vitamin D receptor polymorphisms and BPH risk. Identification of BPH susceptibility by vitamin D receptor gene polymorphisms has potential.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flowchart of study selection based on the inclusion and exclusion criteria.
Figure 2.
Figure 2.
Forest plot of Tap-1 polymorphism and overall population with homozygote model (WW vs ww). CI = confidence interval, OR = odds ratio.
Figure 3.
Figure 3.
Forest plot of Tap-1 polymorphism and overall population with the allelic model (W vs w). CI = confidence interval, OR = odds ratio.
See this image and copyright information in PMC

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References

    1. Lerner LB, McVary KT, Barry MJ, et al. . Management of lower urinary tract symptoms attributed to benign prostatic hyperplasia: AUA GUIDELINE PART I—initial work-up and medical management. J Urol. 2021;206:806–17. - PubMed
    1. Devlin CM, Simms MS, Maitland NJ. Benign prostatic hyperplasia—what do we know? BJU Int. 2021;127:389–99. - PubMed
    1. Qian XQ, Xu D, Liu HL, et al. . Genetic variants in 5p13.2 and 7q21.1 are associated with treatment for benign prostatic hyperplasia with the alpha-adrenergic receptor antagonist. Aging Male. 2017;20:250–6. - PubMed
    1. Na R, Helfand BT, Chen HT, et al. . A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Prostate. 2017;77:1213–20. - PMC - PubMed
    1. AlChalabi R, Wali MH, Al-Ugaili DN, et al. . Association between single nucleotide polymorphisms of vitamin D receptor gene and diabetes with progression of benign prostatic hyperplasia. Ann Trop Med Public Health. 2020;23:444–54.

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