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. 2024 Mar 1:384:e076625.
doi: 10.1136/bmj-2023-076625.

Illness trajectories of incurable solid cancers

Eric C T Geijteman  1 , Evelien J M Kuip  2 , Jannie Oskam  3 , Diana Lees  4 , Eduardo Bruera  5
Affiliations

Illness trajectories of incurable solid cancers

Eric C T Geijteman et al. BMJ. .
No abstract available

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Conflict of interest statement

Competing interests: The BMJ has judged that there are no disqualifying financial ties to commercial companies. The authors declare that they have no competing interests.

Figures

Fig 1
Fig 1
Patients within the traditional disease trajectory gradually deteriorate and then enter a short period of evident decline ending in death. Compared with receiving no treatment, patients treated with chemotherapy or hormonal therapy may live months to years longer
Fig 2
Fig 2
Major temporary improvement: patients who benefit from targeted therapy (drugs to target specific genes and proteins) may respond to such a degree that their condition improves for weeks or even years before their final deterioration
Fig 3
Fig 3
Long term ongoing response. Patients may enter long term, durable remission and receive follow-up care over a longer period
Fig 4
Fig 4
Rapid decline due to adverse event. Patients may die prematurely due to adverse events
Fig 5
Fig 5
Provision of supportive and palliative care in current cancer care
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References

    1. GBD 2017 Causes of Death Collaborators . Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392:1736-88. 10.1016/S0140-6736(18)32203-7. - DOI - PMC - PubMed
    1. National Cancer Institute. Cancer statistics. 2020. https://www.cancer.gov/about-cancer/understanding/statistics.
    1. Sung H, Ferlay J, Siegel RL, et al. . Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209-49. 10.3322/caac.21660. - DOI - PubMed
    1. Murray SA, Kendall M, Boyd K, Sheikh A. Illness trajectories and palliative care. BMJ 2005;330:1007-11. 10.1136/bmj.330.7498.1007. - DOI - PMC - PubMed
    1. Nabholtz JM, Buzdar A, Pollak M, et al. Arimidex Study Group . Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. J Clin Oncol 2000;18:3758-67. 10.1200/JCO.2000.18.22.3758. - DOI - PubMed