Evolving liver disease insights from NAFLD to MASLD

doi:10.1016/j.tem.2024.02.012

Review

. 2024 Aug;35(8):683-686.

doi: 10.1016/j.tem.2024.02.012. Epub 2024 Feb 29.

Evolving liver disease insights from NAFLD to MASLD

Xiude Fan¹, Yongfeng Song², Jiajun Zhao³

Affiliations

¹ Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; 'Chuangxin China' Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, Jinan, Shandong, 250021, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China.
² Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; 'Chuangxin China' Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, Jinan, Shandong, 250021, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China. Electronic address: syf198506@163.com.
³ Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; 'Chuangxin China' Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, Jinan, Shandong, 250021, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China. Electronic address: jjzhao@sdu.edu.cn.

PMID: 38429162
DOI: 10.1016/j.tem.2024.02.012

Review

Evolving liver disease insights from NAFLD to MASLD

Xiude Fan et al. Trends Endocrinol Metab. 2024 Aug.

. 2024 Aug;35(8):683-686.

doi: 10.1016/j.tem.2024.02.012. Epub 2024 Feb 29.

Authors

Xiude Fan¹, Yongfeng Song², Jiajun Zhao³

Affiliations

¹ Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; 'Chuangxin China' Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, Jinan, Shandong, 250021, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China.
² Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; 'Chuangxin China' Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, Jinan, Shandong, 250021, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China. Electronic address: syf198506@163.com.
³ Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; 'Chuangxin China' Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, Jinan, Shandong, 250021, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China. Electronic address: jjzhao@sdu.edu.cn.

PMID: 38429162
DOI: 10.1016/j.tem.2024.02.012

Abstract

The recent renaming of 'non-alcoholic fatty liver disease' (NAFLD) to 'metabolic dysfunction-associated steatotic liver disease' (MASLD) emphasizes metabolic dysfunction in steatotic liver disease and advocates for tailored, comprehensive treatment strategies, driving forward the development of personalized care and innovative therapeutic approaches.

Keywords: metabolic dysfunction; metabolic dysfunction-associated steatotic liver disease; multidisciplinary integrated prevention and treatment; personalized treatment.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest that pertain to this work.

Cited by

Carbon tetrachloride does not promote hepatic fibrosis in ob/ob mice via downregulation of lipocalin-2 protein.
Shin HJ, Kim KE, An HS, Jeong EA, Oh J, Sun Y, Park DJ, Lee J, Yang J, Roh GS. Shin HJ, et al. Redox Biol. 2025 Mar;80:103506. doi: 10.1016/j.redox.2025.103506. Epub 2025 Jan 16. Redox Biol. 2025. PMID: 39832399 Free PMC article.
Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease.
Gong J, Qin Z, Xiao Y, Li J, Wang Q, Lei L, Li J. Gong J, et al. J Inflamm Res. 2025 Jul 5;18:8821-8833. doi: 10.2147/JIR.S525168. eCollection 2025. J Inflamm Res. 2025. PMID: 40635764 Free PMC article.
Coriandrum sativum L. Leaf Extract Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating the AMPK Pathway in High Fat-Fed C57BL/6 Mice.
Gu MJ, Ahn Y, Lee YR, Yoo G, Kim Y, Choi I, Ha SK, Kim D. Gu MJ, et al. Nutrients. 2024 Nov 30;16(23):4165. doi: 10.3390/nu16234165. Nutrients. 2024. PMID: 39683561 Free PMC article.
Role of the E26 transformation specific transcription factor family in metabolic disorders.
Yang M, Gao L, Xu B, Li W, Chen C, Chen J, Zhou J. Yang M, et al. J Endocrinol Invest. 2025 Jul 5. doi: 10.1007/s40618-025-02634-0. Online ahead of print. J Endocrinol Invest. 2025. PMID: 40616738 Review.
Potential therapeutic strategies for MASH: from preclinical to clinical development.
Xie Z, Li Y, Cheng L, Huang Y, Rao W, Shi H, Li J. Xie Z, et al. Life Metab. 2024 Jul 6;3(5):loae029. doi: 10.1093/lifemeta/loae029. eCollection 2024 Oct. Life Metab. 2024. PMID: 39872142 Free PMC article. Review.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Evolving liver disease insights from NAFLD to MASLD

Affiliations

Evolving liver disease insights from NAFLD to MASLD

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Similar articles

Cited by

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Medical