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Meta-Analysis
. 2024 Mar 1;24(1):26.
doi: 10.1186/s12902-024-01556-x.

Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis

Pushpamala Ramaiah  1 , Kamilya Jamel Baljon  1 , Ahmed Hjazi  2 , Maytham T Qasim  3 , Omar Abdulwahid Salih Al-Ani  4 , Shad Imad  5 , Beneen M Hussien  6 , Ali Alsalamy  7 , Nazila Garousi  8
Affiliations
Meta-Analysis

Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis

Pushpamala Ramaiah et al. BMC Endocr Disord. .

Retraction in

Abstract

Background: Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available evidence is contradictory. The aim of this meta-analysis was to assess the association between dietary intake of polyphenols and the odds of MetS.

Methods: The PubMed and Scopus databases were systematically searched to obtain eligible studies. The risk of MetS for the highest versus the lowest intakes of total, subclasses and individual polyphenols were examined by pooling odds ratios (OR) and 95% confidence intervals (95%CI) using the random effects model.

Results: A total of 14 studies (6 cohort and 8 cross-sectional studies) involving a total of 50,366 participants with 10,879 cases of MetS were included. When various polyphenol compounds were pooled, they were significantly related to a 22% decreased odds of MetS (([5 studies]; OR: 0.78; 95%CI: 0.72-0.85). Higher intakes of total flavonoids (([9 studies]; OR: 0.78; 95%CI: 0.72-0.85), flavan-3-ols (([2 studies]; OR: 0.64; 95%CI: 0.43-0.94), isoflavones (([3 studies]; OR: 0.84; 95%CI: 0.75-0.93), stilbenes (([4 studies]; OR: 0.86; 95%CI: 0.76-0.97), flavones (([2 studies]; OR: 0.79; 95%CI: 0.71-0.89), and quercetin (([2 studies]; OR: 0.63; 95%CI: 0.43-0.93) were also significantly associated with a decreased risk of MetS. The associations were not modified by the age of the participants. No association was found for total polyphenols, phenolic acids, lignans, anthocyanins, and flavonols.

Conclusion: The results of this meta-analysis supported that higher polyphenol intake can lower the risk of MetS.

Keywords: Flavonoids; Meta-analysis; Metabolic syndrome; Polyphenols.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the study
Fig. 2
Fig. 2
Meta-analysis of the association between various polyphenolic compounds and risk of MetS. DL: DerSimonian and Laird random effects model
Fig. 3
Fig. 3
Meta-analysis of the association between various polyphenol subclasses and risk of MetS. DL: DerSimonian and Laird random effects model
Fig. 4
Fig. 4
Meta-regression analysis according to the age of participants
Fig. 5
Fig. 5
Funnel plot for publication bias
See this image and copyright information in PMC

References

    1. Alizadeh S, Ahmadi M, Ghorbani Nejad B, Djazayeri A, Shab-Bidar S. Metabolic syndrome and its components are associated with increased chronic kidney disease risk: evidence from a meta‐analysis on 11 109 003 participants from 66 studies. Int J Clin Pract. 2018;72(8):e13201. - DOI - PubMed
    1. Rashidbeygi E, Safabakhsh M, Mohammed SH, Alizadeh S. Metabolic syndrome and its components are related to a higher risk for albuminuria and proteinuria: Evidence from a meta-analysis on 10,603,067 subjects from 57 studies. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019;13(1):830– 43. - PubMed
    1. Alizadeh S, Esmaeili H, Alizadeh M, Daneshzad E, Sharifi L, Radfar H, et al. Metabolic phenotypes of obese, overweight, and normal weight individuals and risk of chronic kidney disease: a systematic review and meta-analysis. Archives Endocrinol Metabolism. 2019;63:427–37. - PMC - PubMed
    1. Razi B, Alizadeh S, Omidkhoda A, Imani D, Rezaei R. Association of chronic hepatitis B infection with metabolic syndrome and its components: meta-analysis of observational studies. Diabetes Metabolic Syndrome: Clin Res Reviews. 2017;11:939–S47. - DOI - PubMed
    1. Askari M, Dehghani A, Abshirini M, Raeisi T, Alizadeh S. Glycemic index, but not glycemic load, is associated with an increased risk of metabolic syndrome: Meta-analysis of observational studies. Wiley Online Library; 2021. p. e14295. - PubMed