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. 2024 May;183(5):2333-2342.
doi: 10.1007/s00431-024-05479-6. Epub 2024 Mar 2.

Galectin-3 levels in children with cystic fibrosis

Dilber Ademhan Tural  1 , Nagehan Emiralioglu  2 , Senay Akin  3 , Didem Alboga  2 , Beste Ozsezen  2 , Halime Nayir Buyuksahin  2 , Ismail Guzelkas  2 , Merve Kasikci  4 , Birce Sunman  2 , Irem Gungor  3 , Ebru Yalcin  2 , Deniz Dogru  2 , Nural Kiper  2 , Ali Haydar Demirel  3   5 , Ugur Ozcelik  2
Affiliations

Galectin-3 levels in children with cystic fibrosis

Dilber Ademhan Tural et al. Eur J Pediatr. 2024 May.

Erratum in

  • Correction to: Galectin-3 levels in children with cystic fibrosis.
    Tural DA, Emiralioglu N, Akin S, Alboga D, Ozsezen B, Buyuksahin HN, Guzelkas I, Kasikci M, Sunman B, Gungor I, Yalcin E, Dogru D, Kiper N, Demirel AH, Ozcelik U. Tural DA, et al. Eur J Pediatr. 2024 Aug;183(8):3633-3634. doi: 10.1007/s00431-024-05585-5. Eur J Pediatr. 2024. PMID: 38761224 No abstract available.

Abstract

Cystic fibrosis (CF) is a multisystemic disease in which airway obstruction, infection, and inflammation play a critical role in the pathogenesis and progression of CF lung disease. The carbohydrate-binding protein Galectin-3 is increased in several inflammatory and fibrotic diseases and has recently been forwarded as a biomarker in these diseases. We aimed to define the role of serum Galectin-3 in children with CF by comparison with healthy subjects. This is a cross-sectional, case-control study. 143 CF and 30 healthy subjects were enrolled in the study. Peripheral blood and sputum concentrations of Galectins-3, interleukin (IL)-17A, IL-8, and neutrophil elastase (NE) were determined with commercial ELISA kits. There was no significant difference between the groups in age and gender (p = 0.592, p = 0.613, respectively). Serum Galectin-3 and NE concentrations were higher in the patient group than in healthy controls (p = 0.002, p < 0.001, respectively). There were no significant differences between groups according to IL-17A and IL-8 concentrations. Serum Galectin-3 was correlated with age (r = 0.289, p < 0.001) and body mass index (BMI) (r = 0.493, p < 0.001) in children with CF. Sputum Galectin-3 levels are negatively correlated with percent predictive forced expiratory volume in 1 s (FEV1) (r = - 0.297, p = 0.029), FEV1 z-score, (r = - 0.316, p = 0.020), percent predictive forced vital capacity (FVC) (r = - 0.347, p = 0.010), and FVC z-score (r = - 0.373, p = 0.006). Conclusion: The study shows that serum Galectin-3 levels increased in clinically stable CF patients, and serum Galectin-3 response may depend on age, gender, and BMI. The sputum Galectin-3 was found to be negatively correlated with patients' lung functions. What is known: • Galectin-3 is a key regulator of chronic inflammation in the lung, liver, kidney, and tumor microenvironment. What is new: • Children with cystic fibrosis (CF) have higher serum Galectin-3 concentrations than healthy children. • Serum Galectin-3 expression influenced by age, BMI, and gender in children with CF.

Keywords: Cystic fibrosis; Galectin-3; Inflammation; Neutrophil elastase; Pediatrics.

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