Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 2;15(1):55.
doi: 10.1007/s12672-024-00920-6.

Effects of different surgical approaches on health-related quality of life in pediatric and adolescent patients with papillary thyroid carcinoma

Yanling Su #  1   2 , Feng Wang #  3 , Shunjin Chen  4 , Xiyu Yao  4
Affiliations

Effects of different surgical approaches on health-related quality of life in pediatric and adolescent patients with papillary thyroid carcinoma

Yanling Su et al. Discov Oncol. .

Abstract

Objective: We aimed to compare the health-related quality of life (HRQOL) in pediatric and adolescent patients with papillary thyroid carcinoma who underwent bilateral or unilateral thyroidectomy.

Methods: This prospective observational study recruited children and adolescents diagnosed with papillary thyroid carcinoma at low risk of recurrence. Participants were categorized into bilateral or unilateral thyroidectomy groups. They were asked to complete one questionnaire regarding basic information and three others regarding quality of life. HRQOL data from patients who underwent different procedures at various time points were compared.

Results: Thirty patients underwent unilateral thyroidectomy and 54 bilateral thyroidectomy (median age = 14.27 years). HRQOL of the unilateral thyroidectomy group was higher than the bilateral group.

Conclusion: For children and adolescents with papillary thyroid carcinoma at low risk of recurrence, bilateral thyroidectomy is associated with a lower HRQOL than unilateral thyroidectomy. Surgeons should consider tumor impact and HRQOL when selecting the most appropriate surgical method.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
THYCA-Qol results in the UT and BT groups. a Score results for neuromuscular symptoms in both groups. b Score results for throat/mouth symptoms in both groups. c Score results for psychological symptoms in both groups. THYCA-Qol: Thyroid Cancer-Specific Quality of Life Questionnaire, BT bilateral thyroidectomy, UT unilateral thyroidectomy. *P < 0.05, **P < 0.01, ***P < 0.001
Fig. 2
Fig. 2
PedsQL results in the UT and BT groups. a Score results for physiological function in the two groups. b Score results for emotional function in the two groups. c Scale total score for the two groups. PedsQL Pediatric Quality of Life Inventory, BT bilateral thyroidectomy, UT unilateral thyroidectomy. *P < 0.05, **P < 0.01, ***P < 0.001
Fig. 3
Fig. 3
EORTC QLQ-C30 results in the UT and BT groups. a Score results for emotional function in both groups. b Score results for global quality of life in both groups. c Score results for fatigue in both groups. EORTC QLQ-C30 European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, BT bilateral thyroidectomy, UT unilateral thyroidectomy. *P < 0.05, **P < 0.01, ***P < 0.001
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Lamartina L, Leboulleux S, Schlumberger M. Thyroid cancer incidence in children and adolescents. Lancet Diabetes Endocrinol. 2021;9(3):128–129. doi: 10.1016/S2213-8587(20)30430-7. - DOI - PubMed
    1. Kotanidou EP, Giza S, Tsinopoulou VR, et al. The prognostic significance of BRAF gene analysis in children and adolescents with papillary thyroid carcinoma: a systematic review and meta-analysis. Diagnostics. 2023 doi: 10.3390/diagnostics13061187. - DOI - PMC - PubMed
    1. Zbitou A, Desandes E, Guissou S, et al. Thyroid cancers in children and adolescents in France: incidence, survival and clinical management over the 2000–2018 period. Int J Pediatr Otorhinolaryngol. 2022;162:111325. doi: 10.1016/j.ijporl.2022.111325. - DOI - PubMed
    1. Matalka L, Rahman AF, Sparks S, et al. Evaluation and management of pediatric thyroid nodules and thyroid cancer at a single institution after adoption of the American thyroid association 2015 guidelines. J Pediatr Endocrinol Metab. 2023;36(7):659–666. doi: 10.1515/jpem-2022-0334. - DOI - PubMed
    1. Erdmann F, Frederiksen LE, Bonaventure A, et al. Childhood cancer: survival, treatment modalities, late effects and improvements over time. Cancer Epidemiol. 2021;71(Pt B):101733. doi: 10.1016/j.canep.2020.101733. - DOI - PubMed

LinkOut - more resources