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. 2024 Apr;43(4):1299-1310.
doi: 10.1007/s10067-024-06918-3. Epub 2024 Mar 4.

Geriatric nutrition risk index: a more powerful index identifying muscle mass loss in patients with rheumatoid arthritis

Jie Pan  1 , Tao Wu  1 , Jian-Da Ma  1 , Pei-Wen Jia  1 , Yao-Wei Zou  1 , Zhi-Ming Ouyang  1 , Hu-Wei Zheng  1 , Jian-Zi Lin, Qian Zhang  1 , Ye Lu  1 , Le-Feng Chen  1 , Ze-Hong Yang  2 , Ying-Ying Zhu  3 , Qing-Yang Song  4 , Yun Su  4 , Lin-Wang Su  4 , Wei Dai  5 , Jun Dai  6 , Lie Dai  7
Affiliations

Geriatric nutrition risk index: a more powerful index identifying muscle mass loss in patients with rheumatoid arthritis

Jie Pan et al. Clin Rheumatol. 2024 Apr.

Abstract

Objective: To explore the association of geriatric nutrition risk index (GNRI), a traditional albumin-body weight calculation, with myopenia in patients with rheumatoid arthritis (RA) and compare its ability to identify myopenia with protein indicators.

Methods: This cross-sectional study was carried out based on a Chinese RA cohort. Clinical data and protein indicators (including albumin, globulin, albumin to globulin ratio, prealbumin, hemoglobin) were collected. GNRI was estimated by serum albumin and body weight. Myopenia was indicated as muscle mass loss measured by bioelectric impedance analysis.

Results: There were 789 RA patients included with mean age 52.6 ± 12.6 years and 77.6% female. There were 41.3%, 18.0%, 27.5%, 13.2% patients with no (GNRI > 98), low (GNRI 92 to ≤ 98), moderate (GNRI 82 to < 92), and major nutrition-related risk (GNRI < 82). There were 406 (51.5%) RA patients with myopenia, RA patients with major nutrition-related risk had the highest prevalence of myopenia (87.5% vs. 73.3% vs. 50.0% vs. 26.1%). Multivariate logistic analysis showed that compared with no risk, RA patients with low (OR = 3.23, 95% CI: 1.86-5.61), moderate (OR = 9.56, 95% CI: 5.70-16.01), and major nutrition-related risk (OR = 28.91, 95% CI: 13.54-61.71) were associated with higher prevalence of myopenia. Receiver operating characteristic curves showed that GNRI (AUC = 0.79) performed a better identifiable ability toward myopenia than serum albumin (AUC = 0.66) or others indicators (AUC range 0.59 to 0.65), respectively.

Conclusion: GNRI, an objective and convenient albumin-weight index, may be preferable for identifying myopenia in RA patients. Key Points • We firstly elucidated the association of GNRI with muscle mass loss among RA patients, and compared its ability to identify muscle mass loss with serum albumin or other protein indicators. • Major nutrition-related risk identified by GNRI showed the highest risk of muscle mass loss, GNRI demonstrated a greater ability to identify myopenia in RA patients. which indicated GNRI was an objective and convenient albumin-weight index to identify myopenia in RA patients.

Keywords: Geriatric nutrition risk index; Muscle mass loss; Myopenia; Rheumatoid arthritis.

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