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Review
. 2024 Mar 3;22(1):230.
doi: 10.1186/s12967-024-05003-2.

Therapeutic potential of mitochondrial transplantation in modulating immune responses post-cardiac arrest: a narrative review

Tomoaki Aoki  1 , Yusuke Endo  1 , Eriko Nakamura  1 , Cyrus E Kuschner  1   2 , Jacob Kazmi  1 , Parmeshar Singh  1 , Tai Yin  1 , Lance B Becker  1   2 , Kei Hayashida  3   4
Affiliations
Review

Therapeutic potential of mitochondrial transplantation in modulating immune responses post-cardiac arrest: a narrative review

Tomoaki Aoki et al. J Transl Med. .

Abstract

Background: Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy, particularly effective in diseases characterized by mitochondrial dysfunction. This review synthesizes current knowledge on MTx, focusing on its role in modulating immune responses and explores its potential in treating post-cardiac arrest syndrome (PCAS).

Methods: We conducted a comprehensive narrative review of animal and human studies that have investigated the effects of MTx in the context of immunomodulation. This included a review of the immune responses following critical condition such as ischemia reperfusion injury, the impact of MTx on these responses, and the therapeutic potential of MTx in various conditions.

Results: Recent studies indicate that MTx can modulate complex immune responses and reduce ischemia-reperfusion injury post-CA, suggesting MTx as a novel, potentially more effective approach. The review highlights the role of MTx in immune modulation, its potential synergistic effects with existing treatments such as therapeutic hypothermia, and the need for further research to optimize its application in PCAS. The safety and efficacy of autologous versus allogeneic MTx, particularly in the context of immune reactions, are critical areas for future investigation.

Conclusion: MTx represents a promising frontier in the treatment of PCAS, offering a novel approach to modulate immune responses and restore cellular energetics. Future research should focus on long-term effects, combination therapies, and personalized medicine approaches to fully harness the potential of MTx in improving patient outcomes in PCAS.

Keywords: Cardiopulmonary resuscitation; Heart arrest; Immune response; Inflammation; Ischemia; Mitochondrial transplantation; Reperfusion injury.

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Conflict of interest statement

All authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Therapeutic potential of mitochondrial transplantation in modulating immune responses. Created with BioRender.com
Fig. 2
Fig. 2
Therapeutic potential of mitochondrial transplantation in modulating immune responses post CA. Created with BioRender.com
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