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. 2024 Mar;20(2):223-225.
doi: 10.3988/jcn.2023.0332.

Atypical Meningoencephalomyelitis Following Varicella Zoster Virus Infection

Guorong Zhang  1 , Chen Liu  1 , Jin Song  1 , Yuzhong Wang  1   2
Affiliations

Atypical Meningoencephalomyelitis Following Varicella Zoster Virus Infection

Guorong Zhang et al. J Clin Neurol. 2024 Mar.
No abstract available

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1. Neuroimaging of the patient with meningoencephalomyelitis following varicella zoster virus infection. A: Magnetic resonance imaging (MRI) of the brain at study entry showing multifocal low-intensity T1-weighted imaging signals, high-intensity T2-weighted fluid-attenuated inversion recovery (FLAIR) signals in the left cerebral hemisphere (arrow), and an enhanced image with no gadolinium enhancement. B: MRI of the brain on day 15. Diffusion-weighted imaging (DWI) of the brain showed high-intensity signals but normal apparent diffusion coefficient signals on the left side of the pons (arrow). C: MRI of the spine on day 15. Midsagittal T2-weighted imaging (T2WI) of the spine showed small multifocal areas of high-intensity signals extending from the cervical to the thoracic vertebrae (arrows). DWI of the spine showed multifocal high-intensity signals in the cervical (arrows). Axial T2WI of the cervical showed high-intensity signals (arrow). D: In MRI of the spine 6 months performed later, T2WI showed that the originally high-intensity signals in the cervical and thoracic vertebrae were significantly reduced. DWI of the spine showed no abnormal signals in the cervical vertebra. E: Somatosensory evoked potentials (SEP) in the bilateral median and tibial nerves were measured on day 16. The bilateral median SEP of our case showed normal interpeak latencies in the N20 component (17.6 ms and 18.7 ms on the left and right, respectively; both within the normal limit of 20 ms), and were poorly differentiated in the P45 component (arrows). Bilateral tibial SEP showed normal interpeak latencies in the P40 component (36.3 ms and 38.3 ms on the left and right, respectively; both within the normal limit of 40 ms). The SEP indicated impairment of the central nervous system.
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