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Review
. 2024 Feb 28;70(1):91-99.
doi: 10.14341/probl13312.

[Fixed ratio combinations GLP-1RA and basal insulin: literature review]

[Article in Russian]
D V Kurkin  1 , D A Bakulin  2 , E I Morkovin  3 , A V Strygin  3 , Ju V Gorbunova  2 , E V Volotova  3 , A I Robertus  2 , I E Makarenko  4 , V B Saparova  4 , R V Drai  5 , V I Petrov  3
Affiliations
Review

[Fixed ratio combinations GLP-1RA and basal insulin: literature review]

[Article in Russian]
D V Kurkin et al. Probl Endokrinol (Mosk). .

Abstract
in English, Russian

The progressive nature of type 2 diabetes mellitus leads to the need for insulin therapy in a significant proportion of patients. Very often start of insulin therapy in type 2 diabetes mellitus (T2DM) is associated with weight gain and a significant increase of hypoglycemia's risk. However, innovative options, such as fixed ratio combinations of glucagon-like peptide 1 receptor agonists (GLP-1RA) and basal insulin, minimize weight gain and hypoglycemia risks and allow a greater proportion of patients to achieve individual glycemic control goals without compromising safety parameters. This review includes a description of the randomized clinical trials, as well as the results of real clinical practice of the use of two currently existing fixed ration combinations of GLP-1RA and basal insulin - iDegLira and iGlarLixi.

Прогрессирующее течение сахарного диабета 2 типа (СД2) приводит к необходимости назначения инсулинотерапии у значительной части больных. Как правило инсулинотерапия при СД2 сопровождается набором массы тела и существенным увеличением риска гипогликемий. Однако современные опции, такие как фиксированные комбинации агонистов рецепторов глюкагоноподобного пептида-1 (арГПП-1) и базального инсулина, позволяют минимизировать набор веса и риск гипогликемий, а также позволяют большей доле пациентов достигать индивидуальных целей гликемического контроля без ухудшения параметров безопасности. Данный обзор включает описание рандомизированных клинических исследований, а также результатов реальной клинической практики применения двух существующих на сегодняшний день фиксированных комбинаций арГПП-1 и базального инсулина — иДегЛира и иГларЛикси.

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