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. 2024 Feb 29;16(1):e12544.
doi: 10.1002/dad2.12544. eCollection 2024 Jan-Mar.

Incidence of young-onset dementia in Italy: The Brescia register study

Barbara Borroni  1   2 , Ilenia Libri  1 , Matteo Rota  3 , Giuliano Binetti  4 , Luisa Benussi  5 , Roberta Ghidoni  5 , Maria Sofia Cotelli  6 , Silvia Fostinelli  4 , Fabio Guerini  7 , Stefano Boffelli  8 , Eugenio Magni  8 , Marta Pengo  9 , Michele Gennuso  9 , Marta Bianchi  6 , Beatrice Cossu  10 , Vincenzo Palomba  11 , Andrea Crucitti  12 , Angelo Bianchetti  7 , Giancarlo Logroscino  13   14 , Alessandro Padovani  1   2
Affiliations

Incidence of young-onset dementia in Italy: The Brescia register study

Barbara Borroni et al. Alzheimers Dement (Amst). .

Abstract

Introduction: The goal of the present work was to assess the incidence of dementia with onset before the age of 65 years (i.e., young-onset dementia [YOD]) and define the frequencies of young-onset Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and dementia with Lewy bodies (DLB) in the general population.

Methods: The study was conducted from January 1, 2019 to December 31, 2019 in Brescia province (population: 1,268,455). During the study period, all new YOD cases (incident YOD) were counted, and all patients' records reviewed. The incidence was standardized to the Italian general population in 2019.

Results: A total of 29 YOD patients were diagnosed. The age-sex standardized incidence rate was 4.58 (95% confidence interval, 3.07-6.58) per 100,000 person-years. No difference in incidence rate between YOD due to AD or FTLD (P = 0.83) and between sexes (P = 0.81) was observed. YOD incidence increased with age, reaching its peak after 60 years.

Discussion: Presenting neurodegenerative YOD phenotypes encompasses both AD and FTLD. Improved knowledge on YOD epidemiology is essential to adequately plan and organize health services.

Keywords: Alzheimer's disease; frontotemporal dementia; incidence; population‐based study; young‐onset dementia.

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Conflict of interest statement

The authors declare no conflicts of interest. Author disclosures are available in the supporting information.

Figures

FIGURE 1
FIGURE 1
YOD age at onset and incidence by age groups and sex (A) and by age groups and phenotypes (B). AD, Alzheimer's disease; F, female; FTLD, frontotemporal lobar degeneration; M, male; YOD, young‐onset dementia.
See this image and copyright information in PMC

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