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. 2024 Feb 26:17:51-59.
doi: 10.2147/CEG.S439275. eCollection 2024.

Clinicopathological Characteristics, Treatment and Prognosis in Duodenal Adenocarcinoma with Liver Metastasis: A SEER-Based Study

Zhengchun Zhu  1 , Hong Liu  2 , Fei Zhong  1
Affiliations

Clinicopathological Characteristics, Treatment and Prognosis in Duodenal Adenocarcinoma with Liver Metastasis: A SEER-Based Study

Zhengchun Zhu et al. Clin Exp Gastroenterol. .

Abstract

Background and objectives: Duodenal adenocarcinoma (DAC) is a rare tumor that is often accompanied by liver metastasis in advanced stages. The aim of this study was to evaluate the correlation between clinicopathological characteristics and survival in DAC patients with liver metastasis, and to explore appropriate treatment options.

Methods: 482 DAC patients with liver metastasis were retrospectively identified from the Surveillance, Epidemiology and End Results (SEER) database (2011-2020). Univariate and multivariate Cox regression analyses were performed to explore the clinicopathological factors related to survival. The Kaplan-Meier method was used to identify the independent risk factors associated with survival.

Results: The 1-year overall survival (OS) and cancer-specific survival (CSS) rates for the entire cohort were 25.4% and 28.3%, and the 5-year OS and CSS rates were 2.4% and 2.9% respectively. Univariable analysis and multivariate analysis identified chemotherapy and surgery as the independent risk factors for OS and CSS. Patients who underwent chemotherapy and surgery had better CSS and OS rates, whereas radiotherapy failed to improve outcomes.

Conclusion: We identified several prognostic factors of DAC with liver metastasis. Chemotherapy and surgery can prolong the survival of DAC patients with liver metastasis, which lays the foundation for identifying the optimal treatment strategy.

Keywords: SEER database; clinicopathological characteristics; duodenal adenocarcinoma; liver metastasis; survival.

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Conflict of interest statement

All authors declare no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Kaplan-Meier method estimated OS and CSS in duodenal adenocarcinoma with liver metastasis stratified by tumor grade, size, and organ metastasis (bone/brain/lung). (A) OS stratified by tumor grade; (B) CSS stratified by tumor grade; (C) OS stratified by size; (D) CSS stratified by size; (E) OS stratified by organ metastasis (bone/brain/lung); (F) CSS stratified by organ metastasis (bone/brain/lung).
Figure 2
Figure 2
Kaplan-Meier method estimated OS and CSS in duodenal adenocarcinoma with liver metastasis stratified by treatment methods. (A) OS stratified by radiotherapy; (B) CSS stratified by radiotherapy; (C) OS stratified by chemotherapy; (D) CSS stratified by chemotherapy; (E) OS stratified by surgery; (F) CSS stratified by surgery.
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