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. 2024 Feb 27:17:969-980.
doi: 10.2147/DMSO.S447809. eCollection 2024.

The Relationship Between UA/HDL and Diabetic Peripheral Neuropathy: A Cross-Sectional Analysis

Ruoxi Zhen  1   2 , Shuqi Wang  1   2 , Shuchun Chen  1   2   3
Affiliations

The Relationship Between UA/HDL and Diabetic Peripheral Neuropathy: A Cross-Sectional Analysis

Ruoxi Zhen et al. Diabetes Metab Syndr Obes. .

Abstract

Purpose: This study was designed to analyze correlations between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and peripheral nerve conduction velocity (NCV) among type 2 diabetes mellitus (T2DM) patients.

Patients and methods: This was a single-center cross-sectional analysis of 324 T2DM patients. All patients were separated into a group with normal NCV (NCVN) and a group with abnormal NCV (NCVA). Patients were also classified into groups with low and high UHR values based on the median UHR in this study cohort. Neurophysiological data including motor and sensory conduction velocity (MCV and SCV, respectively) were measured for all patients.

Results: Relative to patients with low UHR values, those in the high UHR group presented with greater NCVA prevalence (P = 0.002). UHR remained negatively correlated with bilateral superficial peroneal nerve SCV, bilateral common peroneal nerve MCV, bilateral ulnar nerve SCV, and bilateral right median nerve MCV even after adjustment for confounding factors. UHR was identified as an NCVA-related risk factor, with a 1.370-fold increase in NCVA prevalence for every unit rise in UHR (P < 0.001).

Conclusion: These results identify UHR as a risk factor associated with NCVA that was independently negatively associated with NCV among T2DM patients.

Keywords: diabetic peripheral neuropathy; peripheral nerve conduction velocity; type 2 diabetes mellitus; uric acid to high-density lipoprotein cholesterol ratio.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Comparisons of UHR levels in normal peripheral nerve conduction group and abnormal peripheral nerve conduction group in patients with T2DM.*Denotes significance at a P value of <0.05.
Figure 2
Figure 2
Comparisons of prevalence of abnormal peripheral nerve conduction in the High UHR group and Low UHR group for all participants. *Denotes significance at a P value of <0.05.
See this image and copyright information in PMC

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