Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2024 Mar 5;52(4):445-451.
doi: 10.1515/jpm-2023-0243. Print 2024 May 27.

Changes in regional tissue oxygen saturation values during the first week of life in stable preterm infants

Sadaf H Kazmi  1   2 , Sourabh Verma  1   2 , Sean M Bailey  1   2 , Pradeep Mally  1   2 , Purnahamsi Desai  1   2
Affiliations
Observational Study

Changes in regional tissue oxygen saturation values during the first week of life in stable preterm infants

Sadaf H Kazmi et al. J Perinat Med. .

Abstract

Objectives: Near infrared spectroscopy (NIRS) is a non-invasive method for monitoring regional tissue oxygen saturation (rSO2). The purpose of this study is to investigate the changes that occur in cerebral, splanchnic, and renal rSO2 and fractional tissue oxygen extraction (FTOE) in stable preterm infants in the first week of life.

Methods: Prospective observational study of infants born 30-34 weeks gestation at NYU Langone Health between November 2017 and November 2018. Cerebral, renal, and splanchnic rSO2 were monitored from 12 to 72 h of life, and at seven days. Subjects were divided into gestational age (GA) cohorts. Average rSO2, splanchnic cerebral oxygen ratio (SCOR), FTOE, and regional intra-subject variability was calculated at each location at five different time intervals: 0-12 h, 12-24 h, 24-48 h, 48-72 h, and one week of life.

Results: Twenty subjects were enrolled. The average cerebral rSO2 ranged from 76.8 to 92.8 %, renal rSO2 from 65.1 to 91.1 %, and splanchnic rSO2 from 36.1 to 76.3 %. The SCOR ranged from 0.45 to 0.94. The strongest correlation between the GA cohorts was in the cerebral region (R2=0.94) and weakest correlation was in the splanchnic region (R2=0.81). The FTOE increased in all three locations over time. Intra-subject variability was lowest in the cerebral region (1.3 % (±1.9)).

Conclusions: The cerebral region showed the strongest correlation between GA cohorts and lowest intra-subject variability, making it the most suitable for clinical use when monitoring for tissue hypoxia. Further studies are needed to further examine rSO2 in preterm infants.

Keywords: fractional tissue oxygen extraction; near infrared spectroscopy; preterm infants; regional tissue oxygen saturation; splanchnic cerebral oxygenation ratio.

PubMed Disclaimer

References

    1. Pichler, G, Cheung, PY, Aziz, K, Urlesberger, B, Schmolzer, GM. How to monitor the brain during immediate neonatal transition and resuscitation? A systematic qualitative review of the literature. Neonatology 2014;105:205–10. https://doi.org/10.1159/000357162 . - DOI - PubMed
    1. Sood, BG, McLaughlin, K, Cortez, J. Near-infrared spectroscopy: applications in neonates. Semin Fetal Neonatal Med 2015;20:164–72. https://doi.org/10.1016/j.siny.2015.03.008 . - DOI - PubMed
    1. Wijbenga, RG, Lemmers, PM, van Bel, F. Cerebral oxygenation during the first days of life in preterm and term neonates: differences between different brain regions. Pediatr Res 2011;70:389–94. https://doi.org/10.1203/pdr.0b013e31822a36db . - DOI
    1. Van Bel, F, Lemmers, P, Naulaers, G. Monitoring neonatal regional cerebral oxygen saturation in clinical practice: value and pitfalls. Neonatology 2008;94:237–44. https://doi.org/10.1159/000151642 . - DOI - PubMed
    1. Binder, C, Urlesberger, B, Avian, A, Pocivalnik, M, Muller, W, Pichler, G. Cerebral and peripheral regional oxygen saturation during postnatal transition in preterm neonates. J Pediatr 2013;163:394–9. https://doi.org/10.1016/j.jpeds.2013.01.026 . - DOI - PubMed

Publication types

LinkOut - more resources