[Pharmacological therapies for height improvement in pubertal children with short stature]

Abstract

Short stature in puberty significantly affects the physical and mental health of adolescents. The continuous acceleration of skeletal maturation, caused by sex hormones during puberty, limits the time available for growth and poses a considerable challenge for the treatment of short stature. To date, there is still no standardized treatment protocol for this disorder. However, puberty is the last period to improve the final adult height. Currently, commonly used pharmacological treatments in clinical settings include recombinant human growth hormone, gonadotropin-releasing hormone analogs, and third-generation aromatase inhibitors. In recent years, personalized treatment aiming to improve the final adult height has become a key focus in clinical practice. This article provides a comprehensive summary of research on pharmacological therapies for height improvement in pubertal children with short stature, offering valuable insights for healthcare professionals.

Keywords: Aromatase inhibitor; Gonadotropin-releasing hormone analog; Puberty; Recombinant human growth hormone; Short stature.

图1. 青春期矮身材身高管理策略图 在进行青春期矮身材身高管理中要注意：（1）保持充分的医患沟通，获得患儿/患儿家属的知情同意；（2）GnRHa/AI联合rhGH疗程2年以上，谨慎选择。［rhGH］重组人生长激素；［GnRHa］促性腺激素释放激素类似物；［AI］芳香化酶抑制剂。