Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb 15;26(2):194-200.
doi: 10.7499/j.issn.1008-8830.2309015.

[Advancements in the diagnosis and treatment of pediatric acute liver failure]

[Article in Chinese]
Hui Ming  1 , Yi He  1 , Hong-Mei Xu  1
Affiliations
Review

[Advancements in the diagnosis and treatment of pediatric acute liver failure]

[Article in Chinese]
Hui Ming et al. Zhongguo Dang Dai Er Ke Za Zhi. .

Abstract
in English, Chinese

Pediatric acute liver failure (PALF) is a rare and rapidly progressive clinical syndrome with a poor prognosis and significant mortality. The etiology of PALF is complex, and it presents with diverse and atypical clinical manifestations. Accurate diagnosis based on age-related factors, early recognition or prevention of hepatic encephalopathy, and precise supportive treatment targeting the underlying cause are crucial for improving outcomes and prognosis. This article provides a comprehensive review of recent research on the diagnosis and treatment of PALF, aiming to offer guidance for clinical practice.

儿童急性肝衰竭（pediatric acute liver failure, PALF）是一种罕见、病情进展迅速的临床综合征，预后较差，病死率非常高。PALF病因复杂，临床表现多样且不典型，基于年龄的病因诊断、肝性脑病的早期识别、预防及精准的对因支持治疗对改善结局和预后至关重要。该文主要总结PALF诊断及治疗的相关进展，以期为临床工作提供帮助。.

Keywords: Acute liver failure; Child; Diagnosis; Treatment.

PubMed Disclaimer

Conflict of interest statement

所有作者声明无利益冲突。

References

    1. 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组 . 肝衰竭诊治指南（2018年版）[J]. 中华肝脏病杂志, 2019, 27(1): 18-26. DOI: 10.3760/cma.j.issn.1007-3418.2019.01.006. - DOI - PMC - PubMed
    1. Squires JE, Alonso EM, Ibrahim SH, et al. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition position paper on the diagnosis and management of pediatric acute liver failure[J]. J Pediatr Gastroenterol Nutr, 2022, 74(1): 138-158. DOI: 10.1097/MPG.0000000000003268. - DOI - PubMed
    1. Gao Q, Chen J, Zhao C, et al. Combination of plasma exchange and adsorption versus plasma exchange in pediatric acute liver failure: a multicenter cohort study[J]. J Pediatr Gastroenterol Nutr, 2023, 76(6): 710-715. DOI: 10.1097/MPG.0000000000003759. - DOI - PubMed
    1. 刘颖, 孙丽莹, 朱志军, 等. 肝移植治疗儿童急性肝衰竭: 单中心8年治疗经验[J]. 器官移植, 2022, 13(5): 605-610. DOI: 10.3969/j.issn.1674-7445.2022.05.009. - DOI
    1. 马威, 孙娟, 王晓玲, 等. 儿童急性肝衰竭的病因构成分析及短期疗效评价[J]. 中华肝脏病杂志, 2020, 28(11): 959-963. DOI: 10.3760/cma.j.cn501113-20200726-00425. - DOI - PMC - PubMed